漳州地区HPV感染的基因型分布特点与宫颈病变的关系  

Relationship between characteristics of genotype distribution of HPV infection and cervical lesions in Zhangzhou

作　　者：林亚珍[1] 唐忠辉[1] 黄仲庆[1] 孟加榕[2,3] 郭以河[2,3] 潘羡心[2,3] 

机构地区：[1]漳州卫生职业学院基础医学部,漳州363000 [2]中国人民解放军第一七五医院病理科 [3]厦门大学附属东南医院病理科

出　　处：《山西医科大学学报》2014年第12期1147-1150,共4页Journal of Shanxi Medical University

基　　金：漳州市自然科学基金资助项目(ZZ2012J21)

摘　　要：目的探讨人乳头瘤病毒(human papillomavirus,HPV)感染型别在宫颈病变中分布情况。方法应用基因芯片技术对175例宫颈病变患者石蜡组织进行24种HPV基因型别检测。结果 1检测19种基因型,HPV总感染率为45.14%(79/175),HPV单一感染与多重感染分别为74.68%和25.32%,以高危型单一感染组最高,占60.76%,其型别前四位分别是HPV16、HPV59、HPV58、HPV81亚型。2不同年龄组间以年龄≥60岁组阳性率(62.5%)最高,不同年龄段HPV感染差异无统计学意义(P>0.05)。3高危型单一感染HPV组、高危型多重感染HPV组、高低危混合型多重感染HPV组与低危型单一感染HPV组宫颈病变程度比较,差异均有统计学意义(P<0.05)。高危型单一感染HPV组与高危型多重感染HPV组、低危型多重感染HPV组、高低危混合型多重感染HPV组宫颈病变程度比较差异均无统计学意义(P>0.05);高危型多重感染HPV组与低危型多重感染HPV组比较差异无统计学意义(P>0.05)。结论高危型HPV感染是漳州地区妇女宫颈病变中常见亚型,高危型HPV感染增加了宫颈鳞癌的患病风险,而多重感染可能与宫颈病变进展无关。Objective To explore the distribution of different genotypes of human papillomavirus （HPV） infection in cervical lesions.Methods The gene chip technology was used to detect 24 types of HPV genotypes in paraffin tissues from 175 patients with cervical lesions.Results ①Of 19 types of HPV genotypes,the total infection rate of HPV reached 45.14％ （79/175）,with the infection rate of 74.68％ for single infection and 25.32％ for multiple infection.The infection rate of high risk single infection was the highest （60.76％）.The genotypes of HPV infection ranked in the top four were as followed：HPV16,HPV59,HPV58,HPV81.②The infection rate was highest（62.5％）in the patients aged≥60 years.There was no significant difference in the HPV infection among different age patients （P ＞ 0.05）.③The cervical disease degree was significantly different between high risk single infection group,high risk multiple infection group,mixed type multiple infection group and low risk single infection group（P ＜ 0.05）,but not between high risk single infection group and high or low risk multiple infection groups,mixed type multiple infection group（P ＞0.05）.There was no significant difference between high and low risk multiple infection groups（P ＞ 0.05）.Conclusion The high-risk HPV infection is the common genotypes of HPV infection in Zhangzhou.And the high-risk HPV infection could increase the risk of squamous carcinoma of the cervix,while multiple infections may have nothing to do with the development of cervical lesions.

关 键 词：人乳头瘤病毒 基因分型 宫颈病变 

分 类 号：R711.74[医药卫生—妇产科学]