颅脑外伤后头痛治疗中氧与药物联合应用的效果  

Effects of oxygen coupled with drug therapy in the treatment of headache following traumatic brain injury

作　　者：彭慧平[1] 卢晓欣[1] 汤永建[1] 房卫红[1] 韩丹[1] 田君[1] 

机构地区：[1]南京军区福州总医院高压氧科,福州350025

出　　处：《海军医学杂志》2014年第6期452-453,515,共3页Journal of Navy Medicine

摘　　要：目的探讨氧与药物联合应用治疗颅脑外伤后头痛的效果。方法对2010年4月至2012年3月共105例颅脑损伤后头痛患者进行氧与药物联合应用的对照研究。经患者知情同意,医院伦理委员会批准,将105例患者分为3组:高压氧组(42例),舱外高流量氧组(36例)和对照组(27例)。以疼痛视觉模拟评分(VAS)作为头痛治疗效果评价方法。3组患者均进行常规药物治疗,即应用改善微循环、营养神经、镇痛等药物,高压氧组加用高压氧治疗,舱外高流量组加用舱外高流量氧治疗(常压氧)。结果治疗2个疗程后高压氧组、舱外高流量氧组、对照组的VAS评分别为(1.24±1.63)、(3.21±2.12)、(4.13±1.42)分;头痛次数为(1.67±0.62)、(3.87±1.29)、(4.28±0.75)次/周、头痛持续时间分别为(1.48±0.87)、(2.52±0.92)、(4.37±0.96)h。各组比较差异均有统计学意义(P<0.05)。3组患者中高压氧组治愈率最高,舱外高流量氧组效果次之,前2组疗效均优于对照组,各组之间比较差异有统计学意义(P<0.05)。结论对颅脑创伤后头痛患者,联合应用氧与药物治疗是既有效又安全的治疗方案。Objective To explore the effects of oxygen coupled with drug therapy in the treatment of headache following trau -matic brain injury.Methods A comparative study was made on 105 cases of headache induced by traumatic brain injury treated with hyperbaric oxygen （ HBO） coupled with drug therapy from April 2010 to March 2012.The patients were divided into 3 groups：the HBO group （42 cases）, the outside chamber high-flow oxygen group （36 cases） and the control group （27 cases）.The pain visual analog scores （ VAS） were used as a pain assessment method for the treatment efficacy of headache .The patients of 3 groups were all given routine drug treatment , for improvement of microcirculation , nutrition of neural cells and analgesia .The patients in the HBO and the outside chamber high-flow oxygen groups were respectively supplemented with HBO therapy and high-flow oxygen therapy .Results Af-ter two treatment courses , VAS scores for the HBO group , the outside chamber high-flow oxygen group and the control group were re-spectively （1.24 ±1.63）,（3.21 ±2.12）and（4.13 ±1.42）.The number of headache for the 3 groups were respectively（1.67 ± 0.62）times/week,（3.87 ±1.29）times/week and（4.28 ±0.75）times/week.And the durations of headache were respectively （1.48 ± 0.87）h,（2.52 ±0.92）h and（4.37 ±0.96） h.Statistical significance could be noted , when comparisons were made between the 3 groups （P〈0.05）.Results indicated that cure rate of the HBO group was the highest , the outside chamber high-flow oxygen group came the second , which were all superior to that of the control group , and statistical difference could be seen , when comparisons were made between the groups（P〈0.05）.Conclusion For patients with headache following traumatic brain injury , the combined treatment with oxygen and drugs was a safe and effective treatment method .

关 键 词：头痛 创伤 颅脑 氧 高压氧 舱外高流量氧 疼痛视觉模拟评分 

分 类 号：R651.15[医药卫生—外科学]