扑热息痛的制备  

Synthesis of Paracetamol

作　　者：王玉枝[1] 赵兆[1] 路曼[1] 陈海英[1] 张恒[1] 柳喆[1] 吴范宏[1] 殷燕[1] 

机构地区：[1]上海应用技术学院化学与环境工程学院,上海201418

出　　处：《上海应用技术学院学报（自然科学版）》2014年第4期283-285,309,共4页Journal of Shanghai Institute of Technology: Natural Science

基　　金：上海市自然科学基金资助项目(12ZR1431100);上海应用技术学院大学生科技创新项目(PE2014036;PE2014053;DCX2014-020;DCX2014-030);上海应用技术学院研究生2012年课程建设项目

摘　　要：扑热息痛是较阿司匹林更安全的解热镇痛药.以对硝基苯酚为起始原料,经催化加氢和乙酰化两步反应合成制备扑热息痛.两步反应均通过薄层色谱法(TLC)跟踪反应终点,并利用核磁共振仪(NMR)、红外光谱仪(IR)和显微熔点仪(MP)等对产品结构进行了表征.该制备方法具有原料价廉易得、实验操作简单和分离提纯容易等优点.Paracetamol is a safer fever-relieves and pain-killer than aspirin.It was synthesized through hydrogenation and acetylation starting from 4-nitrophenol.Both hydrogenation and acetylation were monitored by thin layer chromatography（TLC）and the reaction products were characterized by testing technologies including nuclear magnetic resonance（NMR）,infrared spectrometer（IR）and MP,etc.This synthesis method of paracetamol was proved to have advantages such as being cheap and available starting material,simple operation and convenient separation and purification.

关 键 词：扑热息痛 催化氢化 酰化反应 

分 类 号：TQ463[化学工程—制药化工]