血浆四种生化指标水平与充血性心力衰竭的关系  

Correlation between the Four Biochemical Indicators in plasma and Congestive Heart Failure

作　　者：许涛[1] 赵楚敏[1] 宋月霞[1] 李莉[1] 徐爱茹 

机构地区：[1]唐山市人民医院心内科,河北唐山063001

出　　处：《医学综述》2014年第24期4600-4601,共2页Medical Recapitulate

摘　　要：目的分析血浆儿茶酚抑素、血管内皮生长因子(VEGF)、基质金属蛋白酶(MMP)及基质金属蛋白酶组织抑制剂(TIMP)水平与充血性心力衰竭的关系。方法选取2011年9月至2013年8月唐山市人民医院收治的48例充血性心力衰竭患者为观察组,并选取同龄的48例健康人员作为对照组,检测并比较两组及观察组中不同心功能分级的血浆儿茶酚抑素、VEGF、MMP、TIMP水平,采用Logistic分析检测指标与疾病的关系。结果观察组血浆儿茶酚抑素、VEGF、MMP-2、MMP-9及TIMP-1水平均高于对照组,观察组心功能分级较高者各指标检测水平高于心功能较低者(P<0.05);Logistic回归分析显示:血浆儿茶酚抑素、VEGF、MMP-2、MMP-9及TIMP-1均是充血性心力衰竭的预测性因子(P<0.05)。结论充血性心力衰竭患者存在明显的血浆儿茶酚抑素、VEGF、MMP及TIMP水平升高的状态,且心功能分级越高者检测水平越高。Objective To analyze the correlation between the plasma catestatin, vascular endothelial growth factor（VEGF） , matrix mctalloproteinase （MMP） , tissue inhibitor of metalloproteinases （TIMP） and congestive heart failure. Methods A total of 48 patients with congestive heart failure in Tangshan City People′s Hospital from Sept. 2011 to Aug. 2013 were selected as observation group, and 48 healthy persons with the same age were included as the control group, then the plasma catestatin, VEGF, MMP and TIMP of the two groups were detected and compared, and the correlation between the detection indexes and diseases was analyzed by Logistic analysis. Results The plasma catestatin, VEGF, MMP-2, MMP-9 and TIMP-1 of the observation group were all higher than those of the control group, and the detection levels of patients with higher cardiac functional grading were all higher than those of patients with lower cardiac functional grading （ P 〈 0.05 ）. Logistic analysis showed that the five indicators were predictive factors for congestive heart failure（P 〈 0.05 ）. Conclusion The ＂plasma catestatin, VEGF, MMP and TIMP of patients with congestive heart failure all show increasing trend, and the higher the cardiac functional grading, the higher the detection levels.

关 键 词：充血性心力衰竭 儿茶酚抑素 血管内皮生长因子 基质金属蛋白酶 基质金属蛋白酶组织抑制剂 血浆 

分 类 号：R541.6[医药卫生—心血管疾病]