吸烟与甲状腺疾病的关系  

Correlation between smoking and thyroid disorders

作　　者：江妍斐 孟帅[1] 张进安[1] 

机构地区：[1]复旦大学附属金山医院内分泌科,上海201508

出　　处：《国外医学（医学地理分册）》2014年第4期279-282,共4页Foreign Medical Sciences：Section of Medgeography

基　　金：上海市金山区卫计委面上项目资助(No.JSKJ-KJMS2013-02)

摘　　要：大规模人口调查统计显示,吸烟能够降低血清TSH,升高FT3、FT4水平,这一作用与是否存在缺碘有直接的相关性,现有资料表明碘充足地区存在这一效应,即吸烟提高了甲状腺功能亢进症的发病率。而在碘缺乏地区,吸烟者非毒性甲状腺肿大的发病率更高且甲状腺体积更大。吸烟者不易患甲状腺癌,尤其是乳头状甲状腺癌,这跟吸烟的年限及吸烟量有关,但这一观点尚需更多的证据支持,且其相关机制尚不清楚。Investigations of large-scale population have indicated that smoking is likely to decrease serum TSH, meanwhile increase serum FT3 and FT4 levels. However, this effect correlates with iodine levels. Data available have showed this effect occurred in iodine-sufficient areas, which further leads to the development of hyperthyroidism. In iodine-insufficient areas, higher nontoxic goiter incidence and lager thyroid volume are found in smokers, who are less likely to suffer from thyroid cancer, especially papillary thyroid carcinoma. This phenomenon is thought to be related to the dosage of smoking, but the mechanism remains unclear, which needs further investigation.

关 键 词：吸烟 甲状腺功能亢进 甲状腺功能减退 非毒性甲状腺肿 分化型甲状腺癌 

分 类 号：R591[医药卫生—内科学]