兔腹主动脉粥样斑块的建立与超声评价  

Establishment and ultrasonic evaluation of rabbit abdominal aorta atheromatous plaque

作　　者：张勇[1,2] 陆永萍[1,2] 周虹[1,2] 袁媛[1,2] 汤跃跃[1,2] 刘蕊[1,2] 李云燕[1,2] 徐丽荣[1,2] 

机构地区：[1]昆明医科大学第四附属医院 [2]云南省第二人民医院超声科,昆明650021

出　　处：《重庆医学》2014年第36期4922-4923,4927,共3页Chongqing medicine

基　　金：云南省自然科学基金面上项目(2011FZ288)

摘　　要：目的制备兔腹主动脉粥样斑块模型,并使用超声监测其形成过程。方法使用高脂饲养法对60只日本雄性大白兔进行喂养(模型组,死亡6只),超声监测其腹主动脉粥样斑块形成的过程,并与20只正常兔对照(正常组),最终通过病理证实。结果模型组52只兔腹主动脉粥样斑块模型制备成功,腹主动脉内中膜复合体厚度明显高于正常组。结论高脂饮食是进行兔动脉粥样硬化模型制备的有效方法,动脉粥样硬化以动脉粥样斑块形成为典型特征,高频超声能很好地评价兔腹主动脉粥样斑块形成的过程及情况。Objective To prepare the rabbit abdominal aorta atheromatous plaque model ,and to monitor its forming process by ultrasound .Methods Totally 60 Japanese male white rabbits（mdel group ,dead 6 rabbits） fed by high fat diet and the abdominal a‐orta atheromatous plaque formation process was monitored by ultrasound ,20 normal rabbits were taken as control .The abdominal aorta atheromatous plaque was finally confirmed by pathology .Results 52 rabbits in the model group were successful in preparing the abdominal aortic plaque model .The thickness of intima‐media complex was obviously higher than that of the control group .Con‐clusion High fat diet is an effective method for preparing the rabbit atherosclerosis model .The arterial atheromatous plaque forma‐tion is the typical characteristic of atherosclerosis .The high frequency ultrasound can better evaluate the formation process and con‐dition of rabbit abdominal aorta atheromatous plaque .

关 键 词：兔腹主动脉 粥样斑块 超声 

分 类 号：R445.1[医药卫生—影像医学与核医学]