新型酸性离子液体催化的Knoevenagel缩合反应  

Knoevenagel Condensation Catalyzed by Novel Acidic Ionic Liquid

作　　者：泮丽亚 李志峰[2] 倪宇翔[2] 姚振刚[1] 余志平 吴文康 应安国[1] 

机构地区：[1]台州学院医药化工学院,台州318000 [2]天津大学化工学院,天津300072 [3]浙江省低碳脂肪胺工程技术研究中心,杭州311604

出　　处：《高等学校化学学报》2015年第1期81-86,共6页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:21106090);国家级大学生创新训练项目(批准号:201410350018);浙江省低碳脂肪胺工程技术研究中心开放基金项目(批准号:2012E10033)资助~~

摘　　要：研究了一类新型酸性离子液体催化的Knoevenagel缩合反应,结果表明,该催化剂适用于一系列芳香/杂环醛与α-取代活性亚甲基化合物间的反应,反应可在室温下进行,反应时间短且收率良好（92%-98%）.该反应体系操作简单,产物易分离.提出了可能的反应机理并对机理进行了验证.该离子液体重复使用5次后仍具有较高的反应活性.A series of novel multiacidic ionic liquids （ [ TEOA ] [ CF3 COO ] ） based on triethanolamine were synthesized through the two-step method and introduced as catalysts for Knoevenagel condensation of complex active methylene compounds. [ TEOA] [ CF3 COO] showed the best catalytic performance. The reactions were carried out at room temperature and the amount of catalyst was only 2%（ molar fraction） . The reaction system was applicable to a wide range of aromatic/heteroaromatic aldehydes with the complex α-substituted active methylene compounds affording the products in excellent yields （ 92%—98%） within minutes. The reaction system was operationally simple and the desired products could be easily separated from the reaction mixture. A plausible mechanism for the Knoevenagel reaction catalyzed by [ TEOA] [ CF3 COO] was proposed and the relevant evidences were given. In addition, the ionic liquid could be regenerated and recycled five times without a significant loss of activity.

关 键 词：新型酸性离子液体 KNOEVENAGEL缩合反应 绿色化学 重复使用性 

分 类 号：O625.67[理学—有机化学]