正交试验优选芒硝的炮制工艺  

Optimization of Processing Technology for Natrii Sulfas by Orthogonal Test

作　　者：郑立枫 孙飞[1] 孟江[1] 王淑美[1] 梁生旺[1] 

机构地区：[1]广东药学院中药学院,国家中医药管理局中药数字化质量评价技术重点研究室,广东高校中药质量工程技术研究中心,广州510006

出　　处：《中国实验方剂学杂志》2015年第1期35-37,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家中医药管理局中医药行业科研专项(201207004-7)

摘　　要：目的:优选芒硝的炮制工艺,为规范其质量控制提供参考。方法:以芒硝中镁离子质量分数为指标,采用正交试验考察芒硝炮制过程中萝卜用量、加水量、芒硝-萝卜共煮时间对炮制工艺的影响。采用原子吸收分光光度法测定镁离子含量,检测波长285.28 nm。测定不同芒硝炮制品中硫酸钠含量。结果:最佳炮制工艺条件为天然芒硝矿石粉末加5倍量水于40℃水浴下搅拌溶解,静置30 min,上清液加0.1倍量萝卜煎煮60 min,于<4℃环境中结晶12 h。镁离子、硫酸钠质量分数分别为7.143μg·g-1和97.83%。结论:优选的工艺稳定可行,提示萝卜提净芒硝具有一定合理性,对规范芒硝的炮制工艺具有一定参考意义。Objective ： To optimize processing technology of Natrii Sulfas. Method ： With the content of magnesium ion in Natrii Sulfas as index, orthogonal test was adopted to optimize processing technology by taking radish addition, water addition and processing time as factors. The content of magnesium ion was determined by atomic absorption spectrophotometry with detection wavelength of 285.28 nm. The content of sodium sulfate in different processed products was measured. Result： The best processing technology was as following： added 5 times the amount of water and 0. 1 times the amount of radish for processing 1 hour. Contents of magnesium ion and sodium sulfate were 7. 143 μg· g-1 and 97.83%, respectively. Conclusion： This optimized processing technology is stable and feasible, it is significant to regulate processing technology of Natrii Sulfas, this paper shows that Natrii Sulfas processed by radish is rational.

关 键 词：芒硝 炮制工艺 镁离子 原子吸收分光光度法 硫酸钠 

分 类 号：R283.6[医药卫生—中药学] R284.2[医药卫生—中医学]