参荷脂肝汤对非酒精性脂肪肝糖、脂、尿酸代谢的影响  

Influence of Shenhe Zhigan Decoction on Metabolism of Sugar,Lipid and Uric Acid in Patients with Nonalcoholic Fatty Liver Disease

作　　者：孙维华[1] 赵新芳[2] 甘霞[2] 

机构地区：[1]石河子市人民医院,新疆石河子832000 [2]石河子大学第一附属医院,新疆石河子832000

出　　处：《中国实验方剂学杂志》2015年第1期186-190,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：新疆兵团科技攻关计划课题(2011BA052)

摘　　要：目的:探讨参荷脂肝汤对非酒精性脂肪肝(NAFLD)(肝郁脾虚兼痰瘀互结证)的糖、脂、尿酸代谢的影响及抗氧化应激作用。方法:将116例NAFLD随机按数字表法分为血脂康组和参荷脂肝组各58例。两组均采用维生素E,10 mg/次,3次/d,口服;辛伐他汀片,10 mg/次,1次/d,口服。血脂康组服用血脂康片,2片/次,2次/d,口服。参荷脂肝组内服参荷脂肝汤,1剂/d。两组疗程均为12周。进行治疗前后肝脾CT比值评价;检测治疗前后甘油三酯(TG),总胆固醇(TC),高密度脂蛋白胆固醇(HDL-C),低密度脂蛋白胆固醇(LDL-C)及血尿酸(SUV)水平;检测治疗前后空腹血糖(FBG)、空腹胰岛素(FINS),并计算胰岛素抵抗指数(HOMA-IR);检测治疗前后超氧化物歧化酶(SOD)和丙二醛(MDA)水平。结果:1脂肪肝疗效:经有序资料卡方分析,治疗后参荷脂肝组肝/脾CT比值改善程度优于血脂康组(P<0.05),参荷脂肝组脂肪肝临床疗效优于血脂康组(P<0.05)。2对糖、脂、尿酸代谢的影响:治疗后参荷脂肝组TG和TC水平低于血脂康组(P<0.01),参荷脂肝组TG和TC异常者例数少于血脂康组(P<0.05);参荷脂肝组FINS和IR低于血脂康组(P<0.01);参荷脂肝组SUV水平低于血脂康组(P<0.01)。3抗氧化应激作用:治疗后参荷脂肝组SOD水平高于血脂康组,MDA水平低于血脂康组(P<0.01)。结论:参荷脂肝汤能调节NAFLD(肝郁脾虚兼痰瘀互结证)患者糖、脂和尿酸代谢,改善胰岛素抵抗(IR),并具有一定的抗氧化应激作用,治疗NAFLD临床疗效优于血脂康。Objective： To discuss the influence of Shenhe Zhigan decoction on sugar, lipid and uric acid metabolism in treating patients with nonalcoholic fatty liver disease （NAFLD） （liver stagnation and spleen deficiency combined with phlegm and blood stasis） and to discuss its resistance to oxidative stress. Method： One hundred and sixteen patients with NAFLD were randomly divided into control group （58 cases） and observation group （58 cases） by random number table. Patients in both groups received orally 10 mg vitamin E thrice daily, and 10 mg simvastatin tablets once daily. Patients in control group added orally 2 Xuezhikang tablets twice daily, and patients in observation group added 1 does Shenhe Zhigan decoction once daily for 12 weeks. Liver and spleen CT ratio were evaluated before and after treatment. Levels of triglyceride （TG）, total cholesterol （TC）, high- density lipoprotein （HDL-C） , low density lipoprotein （LDL-C） and blood uric acid （SUV） were tested before and after treatment. Fasting blood glucose （FBG）, fasting insulin （FINS） were detected and indexe of insulin resistance （HOMA IR） was calculated. Levels of superoxide dismutase （SOD） and malondialdehyde （MDA） were tested before and after therapy. Result：① Fatty liver curative effects the improvement of liver/spleen CT ratio in observation group was superior to that in control group （P 〈 0.05） by the chi-square test order data. Besides,curative effect of fatty liver in observation group was better than that in control group （P 〈0. 05 ）. ②Influence of sugar, lipid and uric acid metabolism TG and TC levels in observation group were lower than those in control group （ P 〈 0.01 ）, Abnormal cases of TG and TC in observation group were less than those in control group （P 〈 0.05 ）. FINS and IR levels in observation group were lower than theses in control group （P 〈0.01 ）. Level of SUV in observation group was inferior to that in control group （P 〈0. 01 ）. ③Res

关 键 词：非酒精性脂肪肝 参荷脂肝汤 血尿酸 胰岛素抵抗 氧化应激 

分 类 号：R287[医药卫生—中药学]