中药川楝子研究进展  

Research Advances of Toosendan Fructus

作　　者：李振华[1,2] 鞠建明[1] 华俊磊[1,2] 石慧慧[1] 

机构地区：[1]江苏省中医药研究院中药分析与代谢组研究室,南京210028 [2]南京中医药大学药学院,南京210046

出　　处：《中国实验方剂学杂志》2015年第1期219-223,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81102467);天然药物活性组分与药效国家重点实验室开放课题(SKLNMKF201208-1)

摘　　要：通过对近年来国内外川楝子相关研究文献的整理和分析,分别概述了川楝子化学成分、药理作用及其毒性与代谢组学的最新研究进展。据统计,到目前为止从川楝子中共分离鉴定了挥发油类成分42个,楝烷型三萜及柠檬苦素类化合物6个,黄酮类化合物9个,其他成分33个。川楝子的药理活性研究包括驱蛔杀虫、抗肿瘤、抗病毒、呼吸抑制、抗氧化、抑制破骨细胞、镇痛等作用。川楝子具有一定的药物毒性,作者从吸收与代谢角度阐明了川楝子配伍减毒机制,揭示了其配伍减毒的合理性和科学内涵。川楝子作为传统中药临床应用十分广泛,目前国内外对其药理作用的研究主要集中在楝烷型三萜及柠檬苦素类化合物,但对于其药效物质基础的系统研究则较为有限。为使川楝子安全、有效的应用于临床,建议将血清药物化学和PK/PD结合进行综合分析,寻找其体内药效物质基础。By reviewing the literatures in recent years, the latest progress on chemical components, pharmacology, toxicity studies and metabonomics of Toosendan Fructus have been arranged and analysed. The previous researchs have shown that toosendanin, isolated from Toosendan Fructus, have certain toxicity. The summary not only illustrated the compatibility attenuated mechanism of Toosendan Fructus based on absorption and metabolism, but also revealed its rational and scientific connotations of compatibility. As a traditional Chinese herb Toosendan Fructus has been extensively applied in clinics. However, the current researchs about pharmacological effect of Toosendan Fructus are focused on its neem alkyl-type triterpenoids and limonoids compounds, So far, there is limited systemic research on therapeutic material basis of Toosendan Fructus. In order to ensure its safe and effective application in clinics, the therapeutic basis in vivo should be seeked by comprehensive analysis using serum chemistry combined PK/PD studies.

关 键 词：川楝子 化学成分 药理作用 毒性 配伍减毒 代谢组学 

分 类 号：R285.5[医药卫生—中药学] R284.1[医药卫生—中医学]