酮洛芬固体脂质纳米粒的制备  

Preparation of ketoprofen solid lipid nanoparticles

作　　者：李楠[1] 孔令钰[1] 刘佩莉[1] 李锡晶[1] 王倩[1] 

机构地区：[1]天津市医药科学研究所,天津300020

出　　处：《天津药学》2014年第6期18-22,共5页Tianjin Pharmacy

基　　金：天津市卫生局科技基金资助项目(No.2012KY32)

摘　　要：目的:微乳法制备固体脂质纳米粒,以酮洛芬作为模型药物,考查其载药性能。方法:通过对空白微乳粒径和稳定性考查,确定优化处方,将其保温分散于冷水中制备固体脂质纳米粒。对影响其质量的工艺因素和处方因素进行考查和优化设计,筛选最优处方。结果:制备固体脂质纳米粒的直接影响因素包括脂质用量、药物的用量、冷水相温度和微乳保温温度等,所得固体脂质纳米粒的平均粒径(143.9±1.2)nm,多分散系数为0.443。载药固体脂质纳米粒包封率为81.47%,载药量为8.16%。结论:该法稳定可靠,可用于酮洛芬固体脂质纳米粒的制备。Objective： To prepare solid lipid nanoparticles by microemulsion technique, using ketoprofen as model drug to SLN and to investigate the drug loading capacity of SLN. Methods ： Through the blank microemulsion particle size and stability test, de- termine the optimal prescription. Selection and optimization of microemulsion, the dispersed in cold water in the preparation of SLN. The influence on the quality of process factors and prescription was studied and optimized design, optimize the formulation. Results ： The results showed that stearic acid dosage, dosage of ketoprofen, cold water temperature and heat preservation of microe- mulsion were the key factors that influence the preparation process of SLN, the mean size was （ 143.9 ± 1.2） nm with polydispersi- ty index of 0. 443. The best entrapment efficiency of KP - SLN was found to be 81.47% , the drug was 8.16%. Conclusion： This method is stable and reliable and can be used for ketone ibuprofen solid lipid nanoparticle preparation.

关 键 词：酮洛芬 微乳法 固体脂质纳米粒 包封率 

分 类 号：TQ460.6[化学工程—制药化工]