以唾液样本验证对乙酰氨基酚延迟释放片体内过程  

The Formulation Proof of Acetaminophen Delayed - Release Tablets in Vivo

作　　者：王鹏[1] 李春茹[2] 沈振宏 王东凯[3] 杨永钢[4] 李海燕 

机构地区：[1]沈阳华泰药物研究所,沈阳110015 [2]沈阳东宇药业有限公司,沈阳110036 [3]沈阳药科大学,沈阳110015 [4]中国医科大学,沈阳110001 [5]沈阳克达药厂,沈阳110041

出　　处：《药物分析杂志》2002年第4期306-308,共3页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的:确证压制(干压)包衣延迟释放片衣层处方。方法:以对乙酰氨基酚为模型药,采用HPLC法测定人口服延迟释放片后唾液中药物浓度。结果:包衣所制延迟释放片在体内具显著延迟释放作用,t_(max)为7.72h。结论:建立了压制包衣延迟释放片衣层处方的体内确证方法。Objective: To prove coat formulation of the delayed release tablets in vivo. Method: Acetaminophen was used as the modei drug in saliva of five healthy subjects after oral administration of delayed - release tablets (DRT) by HPLC. Results: The release of acetaminophen from DRT was delayed significantly. tmax was 7. 72 h. Conclusion: A method was developed for proof of formulation for delayed - release tablets in vivo.

关 键 词：压制包衣 延迟释放片 衣层处方 对乙酰氨基酚 唾液 HPLC法 

分 类 号：R927.1[医药卫生—药学]