乳癖消颗粒抗炎镇痛作用实验研究  

Anti-inflammatory and Analgesic Activity of Rupixiao Granules

作　　者：钟璐[1,2,3] 纪宏宇[1,2,3] 王树圆 刘红梅[1,3] 张一丹[1,2,3] 吴琳华[1,2,3] 

机构地区：[1]哈尔滨医科大学附属第二医院药学部,哈尔滨150086 [2]哈尔滨医科大学药学院 [3]黑龙江省高校重点实验室

出　　处：《中国药师》2015年第1期149-151,共3页China Pharmacist

基　　金：黑龙江省科技攻关重大项目(编号:GA13C101);黑龙江省青年科学基金项目(编号:QC2011C104)

摘　　要：目的:研究乳癖消颗粒的抗炎、镇痛作用。方法:采用二甲苯致小鼠耳廓肿胀实验观察乳癖消颗粒的抗炎作用。采用醋酸致小鼠扭体反应实验和小鼠热板法实验观察乳癖消颗粒的镇痛作用。结果:与空白对照组相比,乳癖消颗粒低、中、高剂量组(生药量分别为1.0、2.0和4.0 g·kg·d-1)均能显著抑制小鼠耳肿胀度(P<0.05或P<0.001),且能显著减少醋酸引起的小鼠扭体反应次数(P<0.01或P<0.001);中、高剂量组可提高小鼠热板痛阈值(P<0.05或P<0.01)。结论:乳癖消颗粒具有显著的抗炎镇痛作用。Objective： To investigate the anti-inflammatory and analgesic effects of Rupixiao granules. Methods ： Activity of Rupixi- ao granules against xylene-induced ear edema in mice was measured to evaluate the anti-inflammatory effect, while the analgesic effect was evaluated by acetic acid induced writhing test and hot plate test in mice. Results： Compared with the control group, Rupixiao gran- ules groups （ 1.0, 2.0 and 4.0 g . kg . d- 1 ） could significantly inhibit ear swelling in mice （ P 〈 0.05 or 0.001 ）, and reduce the acetic acid induced writhing times（ P 〈 0.01 or 0.001 ）. Rupixiao granules at medium and high dose could significantly increase the pain thresh- old of mice in the hot plate test. Conclusion： Rupixiao granules exhibit significant anti-inflammatorv and analgesic activities.

关 键 词：乳癖消颗粒 抗炎 镇痛 

分 类 号：R285.5[医药卫生—中药学]