三升金丹胶囊的一般药理实验  

Study on General Pharmacology of Sansheng Jindan Capsules

作　　者：黄凤娇 庞聪[2] 惠晓琳 李继洪[2] 

机构地区：[1]湖北省食品药品监督检验研究院,武汉430064 [2]湖北省医药工业研究院有限公司

出　　处：《中国药师》2015年第1期164-166,共3页China Pharmacist

摘　　要：目的:观察三升金丹胶囊的一般药理作用,为临床用药和安全用药提供信息。方法:采用一般行为观察实验、戊巴比妥钠阈下催眠实验、自发活动实验、转棒实验考察供试品对小鼠中枢神经系统的影响,三升金丹胶囊低中高剂量分别为90,180,360 mg·kg-1;通过检测麻醉状态下Beagle犬的血压、心电及呼吸参数来考察供试品对犬心血管系统及呼吸系统的影响,三升金丹胶囊低中高剂量分别为16,32,64 mg·kg-1。结果:小鼠给予供试品后无异常行为出现、供试品与戊巴比当钠无协同催眠作用、供试品对小鼠的自发活动及机体的协调能力没有影响(P>0.05),对麻醉状态下Beagle犬的血压、心电及呼吸也无明显影响(P>0.05)。结论:在所设计的剂量水平下,三升金丹胶囊对小鼠中枢神经系统、对犬呼吸系统和心血管系统无明显影响。Objective： To study the general pharmacological effects of Sansheng Jindan capsules to provide an experimental basis for the clinical application. Methods： The influence of Sansheng Jindan capsules respectively at the low, medium and high dosage of 90,180 and 360 mg. kg-l on general central nervous system （CNS） of mice was investigated by general behavior observation, nembu- tal subthreshold hypnosis experiment, spontaneous activity test and rotary rod test. The changes in blood pressure, heart rate, electro- cardiogram, breathing flow and frequency in anaesthetic Bealge dogs were observed to evaluate the effects of the capsules respectively at the low, medium and high dosage of 16,32 and 64 mg . kg- 1 on cardiovascular and respiratory systems. Results： The general behavior of mice was normal after the administration of Sansheng Jindan capsules. The capsules showed no synergetic hypnotic effect on nembu- tal, and had no influence on the spontaneous activity and body coordination ability of mice （ P 〉 0.05 ）. The blood pressure, ECG and respiratory index of anaesthetic Bealge dogs were also normal after the administration of the capsules （ P 〉 0.05 ）. Conclusion： There arc no significant effects of Sansheng Jindan capsules at the experimental dosages on central nervous system of mice and respiratory and cardiovascular systems of Beagle dogs.

关 键 词：三升金丹胶囊 一般药理 中枢神经系统 心血管系统 呼吸系统 

分 类 号：R285.5[医药卫生—中药学]