苏黄止咳胶囊治疗感冒后咳嗽临床观察  

Clinical Observation on Suhuang Zhike Capsule for Patients with Post-cold Cough

作　　者：张静[1] 张纾难[2] 王雪京[2] 李颖[2] 

机构地区：[1]厦门市中医院,福建厦门361000 [2]北京卫生部中日友好医院,北京100029

出　　处：《辽宁中医药大学学报》2015年第1期107-110,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：首都医学科技发展基金资助项目(SF2009I07)

摘　　要：目的:观察苏黄止咳胶囊治疗感冒后咳嗽(风咳证,风邪犯肺)临床的有效性、安全性及独特性。方法:采用随机密闭信封法,以西药镇咳药——可愈糖浆为对照组,纳入西医诊断符合感冒后咳嗽,中医诊断符合风咳证风邪犯肺患者共36例,其中治疗组24例,对照组12例,治疗7 d,通过观察患者疗效自评、临床咳嗽疗效、中医症状疗效、咳嗽自测评分及安全性指标,对两组进行疗效评价及安全性评价,探讨其治疗的独特性。结果:临床咳嗽疗效比较,治疗组愈显率54.2%,总有效率83.3%;对照组愈显率25.0%,总有效率75.0%;两组临床疗效评价差异无统计学意义(P=0.12>0.05);中医症状疗效评价,治疗组愈显率29.2%,总有效率95.8%;对照组愈显率16.6%,总有效率58.4%,治疗组总疗效优于对照组,差异具有统计学意义(P=0.026<0.05)。患者疗效自评及咳嗽自测评分比较,治疗组均优于对照组,差异具有统计学意义(分别为P=0.018<0.05,P=0.005<0.05)。安全性评价:治疗组有1例服药后出现腹泻,停药缓解,后继续服用症状未再出现,考虑与药物关系不大。两组安全性指标治疗前后未发生有明确统计学意义的变化。结论:苏黄止咳胶囊治疗感冒后咳嗽有效、安全,具有独特性。Objective ： To observe the effect, safety and specificity of Suhuang Zhike Capsule on postcold cough of wind evil invading lungs syndrome. Methods ： With random closed envelope method, Codeine and Guaifenesin Syrup as the positive control drug, 36 patients which diagnosed as post-cold cough in western medicine and wind evil invading lungs syndrome in traditional chinese medicine （ TCM ） were divided into two groups. The treatment group had 24 patients while the control group 12. Both were treated for 7 days. We assessed the total efficacy and safety from self efficacy evaluation, clinical efficacy, TCM syndrome efficacy, cough self testing scores and safety index in the two groups and discussed the specificity of treatment. Results ： In the comparison of clinical efficacy, the cured-effective rate and the total effective rate was 54.2% and 83.3% in the treatment group, which had no difference to those in the control group 25.0% and 75.0%, respectively （P=0.12〉0.1）. Analysis on TCM syndrome efficacy showed the superiority of the treatment group to the control group with the cured-effective rate and the total effective rate was 29.2% vsn16.6% and 95.8% vsn58.4%, respectively （P=0.026〈0.05）. Analysis on the self efficacy evaluation and cough self testing scores also showed the superiority to the control group （ respectively P=0.018〈0.05, P=0.005〈0.05 ）. Assessment on safety： 1 patient once suffered from diarrhea and felt relieved after stopped to the treat. This supposed had not much to do with the SuHuang ZhiKe Capsule. At the same time, the safety indexes of two groups had no statistically significant changes during this treatment. Conclusion ： Suhuang Zhike Capsule is effective, basically safe and has specificity for the treatment of post-cold cough.

关 键 词：苏黄止咳胶囊 感冒后咳嗽 临床观察 可愈糖浆 中医症状积分 

分 类 号：R441.5[医药卫生—诊断学]