高脂血症人群的血清游离脂肪酸水平调查  

Survey on serum free fatty acids levels in patients with hyperlipidemia

作　　者：辛续丽[1] 杨桂花[1] 韩静[1] 张曼[1] 

机构地区：[1]首都医科大学附属北京世纪坛医院临床检验中心,北京100038

出　　处：《国际检验医学杂志》2015年第1期10-11,共2页International Journal of Laboratory Medicine

基　　金：国家高技术研究发展计划(863计划)资助项目(2011AA02AA11);首都卫生发展科研专项(2011-2008-02)

摘　　要：目的探索血清游离脂肪酸(FFA)在高脂血症人群和血脂正常人群中不同年龄及性别之间的差异。方法选择912例健康体检者(健康对照组)和1 061例高脂血症者,分别测定血清游离脂肪酸(FFA)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和体质量指数(BMI),用协方差分析探讨不同性别、年龄组之间FFA的差别,多元相关分析探讨高脂血症患者FFA与各项血脂指标的关系。结果高脂血症中年女性、中年男性、青年男性的FFA水平较相应对照组明显升高;高脂血症青年女性的FFA水平低于高脂血症其他人群;在血脂正常人群中,老年组的FFA水平明显高于中青年组。结论不同性别、不同年龄高脂血症人群之间的FFA水平有差异。Objective To explore the differences of serum free fatty acids（FFA） between the hyperlipidemia group and the healthy people with different ages and genders. Methods 912 healthy individuals of physical examination （healthy control group） and 1061 patients with hyperlipidemia were selected and detected the serum FFA,total cholesterol,triglyceride,high density lipoprotein-cholesterol,low density lipoprotein-cholesterol, fasting plasma glucose and body mass index. The covariance analysis was used to investigate the differences in the level of serum FFA among different genders and age groups. The relationship between serum FFA and other serum lipids index in the patients with hyperlipidemia was analyzed by the multiple correlation analysis. Results The serum FFA level in the middle-aged females, middle-aged males and young males with hyperlipidemia was higher than that in the corresponding control groups;the serum FFA level in the young females with hyperlipidemia was lower than that in the other groups with hyperlipidemia;in the population groups with normal blood lipid, the serum FFA level in the old-age group was significantly higher than that in the middle-age and young group. Conclusion There is a difference in the serum FFA level in the hyperlipidemia group with different ages and genders.

关 键 词：高脂血症 游离脂肪酸 年龄 性别 

分 类 号：R589.2[医药卫生—内分泌] R446.11[医药卫生—内科学]