大剂量甲钴胺联合灯盏花注射液治疗糖尿病足对TNF-α、CRP水平及AT-Ⅲ活性的影响  

Influence of large dose of mecobalamin combined with breviscapine injection for treating diabetic foot on TNF-αand CRP levels and antithrombin Ⅲ activity

作　　者：叶青跃[1] 杨扬[1] 杜丹心 程鹏飞[2] 张明洁[1] 

机构地区：[1]武汉科技大学附属天佑医院,湖北武汉430064 [2]武汉大学医院,湖北武汉430071

出　　处：《国际检验医学杂志》2015年第1期17-19,共3页International Journal of Laboratory Medicine

基　　金：湖北省教育厅重点科研项目(D20101109);湖北省教育厅教学项目(2008008);武汉科技大学引进人才科研启动基金(530012)

摘　　要：目的观察大剂量甲钴胺联合灯盏花注射液对糖尿病足(DF)患者血清肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平及抗凝血酶Ⅲ(AT-Ⅲ)活性的影响。方法 240例DF患者按随机数字表法分为4组:大剂量甲钴胺+灯盏花注射液治疗组60例(Ⅳ组),常规剂量甲钴胺+灯盏花注射液治疗组60例(Ⅲ组),单纯灯盏花注射液治疗组60例(Ⅱ组),单纯常规剂量甲钴胺治疗组60例(Ⅰ组),4周为1疗程。治疗前后检测TNF-α、CRP水平及AT-Ⅲ活性并进行对比分析。结果治疗前4组血清TNF-α、CRP及AT-Ⅲ检测结果之间差异无统计学意义(P>0.05);分别行治疗前后比较,4组治疗后血清TNF-α及CRP结果均较治疗前降低,AT-Ⅲ水平升高,差异有统计学意义(P<0.05);Ⅳ组与Ⅰ、Ⅱ、Ⅲ组治疗后比较,差异有统计学意义(P<0.05)。结论甲钴胺联合灯盏花注射液能降低DF患者血清中炎性因子如TNF-α及CRP的水平,并使AT-Ⅲ活性升高,尤其是甲钴胺浓度增加时效果更显著。因此,采取增加甲钴胺浓度联合灯盏花注射液的治疗方法能更明显地降低DF的炎症反应,且安全性好,是提高治疗DF的有效手段之一。Objective To observe the influence of large dose of mecobalamin combining with breviscapin injection on the levels of serum tumor necrosis factor-α（TNF-a） and C-reactive protein （CRP） and the antithrombin Ⅱ （AT-Ⅱ ） activity in the patients with diabetic foot（DF）. Methods 240 cases of DF were divided into 4 groups according to the random number table method,60 cases in each group：the large dose of mecobalamin plus breviscapin injection group （group Ⅳ ） ;the routine dose of mecobalamin plus brevis- capin injection group （group Ⅲ）;the simple breviscapin injection group （group Ⅱ ） and the routine dose of mecobalamin group （group Ⅰ）. 4 weeks were taken as a course of treatment. The TNF-α,CRP levels and the AT-Ⅲ activity before and after the treatment were detected and performed the comparative analysis. Results The levels of TNF-α,CRP and AT-Ⅲ before treatment had no statistically significant differences among in the four groups （P〉0.05）. Compared with the results before treatment, the levels of TNF-αand CRP after treatment in 4 groups were obviously decreased and the AT-Ⅲ level was significantly increased, the differences had statistical significance （P〈0.05）;compared with the group Ⅰ , Ⅱ and Ⅲ, the difference in the group IV had statistical significance（P〈0.05）. Conclusion Mecobalamin combined with breviscapin injection is able to decrease the serum inflammatory factors such as TNF-αand CRP,and increase the AT-Ⅲ activity in the patients with DF,which is more significant when increasing the mecobalamin concentration. Therefore,adopting the therapeutical scheme of increasing the mecobalamin concentration combined with breviscapin injection could obviously decrease the inflammatory reaction of DF with good safety, which is one of effective measures for increasing the curative effect of DF.

关 键 词：糖尿病足 甲钴胺 灯盏花注射液 

分 类 号：R587.2[医药卫生—内分泌]