跳远运动员血管紧张素转化酶基因插入/缺失多态性研究  

Polymorphism of angiotensin-converting enzyme gene I/D of broad jumpers

作　　者：张坤[1] 江雪[2] 鲜贵平 胡小川[1] 张俊英[1] 杨浩[1] 余大伟[1] 邓文骞[3] 戴小珍[1] 

机构地区：[1]成都医学院生物医学系,成都610500 [2]重庆市第一人民医院皮肤科,400011 [3]成都体育学院运动医学系,成都610041

出　　处：《重庆医学》2015年第1期18-20,共3页Chongqing medicine

基　　金：国家自然科学基金资助项目(81301919);国家自然科学基金资助项目(81200917);省级大学生创新创业训练计划项目(201313705026);成都医学院大学生创新实验计划(CXJS201310)

摘　　要：目的研究汉族跳远运动员血管紧张素转化酶(ACE)基因插入/缺失(I/D)多态分布特点。方法采用PCR扩增、DNA测序、Hardy-Weinberg遗传平衡定律、SPSS统计学分析跳远运动员ACE基因I/D多态性特点,并与普通人群。结果ACE基因16号存在II、DD、ID 3种,Hardy-Weinberg检验结果显示该研究受试对象具有群体代表性。跳远运动员ACE基因DD型和D等位基因明显高于普通汉族人群(P<0.05)。结论 ACE基因DD型和D等位基因可作为跳远运动员遗传选材的分子标记。Objective To explore the characteristic of ACE gene I/D polymorphism in Han broad jumpers .Methods Distribu-tion of ACE gene I/D polymorphism for broad jumpers was analyzed by PCR ,DNA sequencing ,Hardy-Weinberg and SPSS ,and the results were compared with that of normal people .Results There were II ,DD and ID in gene ACE 16 ,and the Hard-Weinberg re-sults showed that the subjects were group representative .The ACE DD genotype and D allele in broad jumpers was statistically higher than normal controls （P〈0 .05） .Conclusion The results suggest that ACE DD genotype and D allele are associated with training sensitivity of broad jumpers and could be the molecular marker for athletes choosing genetically .

关 键 词：体育运动 跳远运动员 肽基二肽酶A I/D多态 

分 类 号：G823.3[文化科学—体育训练] G804.2[文化科学—体育学]