1-磷酸鞘氨醇及脂联素在支架内再狭窄患者中的预测价值  

The predictive values of sphingosine-1-phosphate and adiponectin in patients with in-stent restenosis

作　　者：杨海燕[1] 景小东[2] 熊焰[1] 王喜春[1] 陈永[1] 

机构地区：[1]重庆市第三人民医院老年科,400014 [2]重庆医科大学第二附属医院心血管内科,400013

出　　处：《重庆医学》2015年第1期40-41,44,共3页Chongqing medicine

基　　金：重庆市卫生局科研基金资助项目(2013-2-090)

摘　　要：目的探讨1-磷酸鞘氨醇(S1P)及脂联素在冠状动脉支架植入术后的预测价值。方法选择经复查冠脉造影后证实为支架内再狭窄患者50例为再狭窄组,选取同时期支架内无再狭窄者50例为对照组,收集研究对象的临床相关资料,分别检测其血清1-磷酸鞘氨醇(S1P)、HDL-S1P、脂联素及IL-18水平,分析其与支架内再狭窄的相关性。结果与对照组比较,再狭窄组血清总S1P水平更低[(96.10±26.33)ng/mL vs.(113.40±32.72)ng/mL,P<0.01],HDL-S1P水平明显降低[(32.81±10.02)ng/mL vs.(42.72±11.75)ng/mL,P<0.01],脂联素水平也明显降低[(7.38±2.11)mg/L vs.(9.25±3.29)mg/L,P<0.01],而两组间IL-18水平则差异无统计学意义[(258.15±82.19)ng/L vs.(224.98±84.15)ng/L,P>0.05];脂联素与S1P(r=0.712,P<0.05)及HDL-S1P(r=0.821,P<0.01)之间均呈正相关。结论 S1P及脂联素是冠脉支架内再狭窄的独立预测因素,相对较高的S1P及脂联素浓度能降低经皮冠状动脉介入治疗(PCI)术后患者支架内再狭窄的风险。Objective To investigate the predictive value of sphingosine-1-phosphate （S1P） and adiponectin after coronary stent implantation .Methods Fifty patients confirmed by coronary angiography with in-stent restenosis were selected as in-stent restenosis group while 50 patients without in-stent restenosis were chose as control group .All cases were detected with the density of their serum S1P ,HDL-S1P ,adiponectin and IL-18 and analyzed relevance to in-stent restenosis .Results Compared with the control group ,serum S1P in in-stent restenosis group were lower [ （96 .10 ± 26 .33）ng/mL vs .（113 .40 ± 32 .72）ng/mL ,P〈0 .01] ,and the levels of HDL-S1P and adiponectin were also significant lower [（32 .81 ± 10 .02）ng/mL vs .（42 .72 ± 11 .75）ng/mL ,P〈 0 .01 ;（7 .38 ± 2 .11）mg/L vs .（9 .25 ± 3 .29）mg/L ,P〈 0 .01] .IL-18 levels between the two groups had no significantly difference [（258 .15 ± 82 .19）ng/L vs .（224 .98 ± 84 .15）ng/L ,P〉0 .05] .Adiponectin showed a positive correlation between S1P （r=0 .712 , P〈0 .05） and HDL-S1P （r=0 .821 ,P〈0 .01） .Conclusion S1P and adiponectin could be independent predictive factor of coronary stent restenosis ,and high concentrations of S1P and adiponectin may reduce risk of in-stent restenosis in patients with stenting percutaneous coronary intervention （PCI） .

关 键 词：磷酸类 鞘氨醇 脂联素 支架内再狭窄 

分 类 号：R541.4[医药卫生—心血管疾病]