苗药黑骨藤配伍金铁锁不同提取物的镇痛抗炎作用研究  

Experimental Study on Anti-inflammatory and analgesic Effects of Different Extracts from the compatibility of Miao medicinal herbs Psammosilene tunicoides and Periploca forrestii

作　　者：王文春[1] 李江[1] 童宏龙 

机构地区：[1]贵阳中医学院,贵州贵阳550002

出　　处：《时珍国医国药》2014年第12期2821-2823,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.81160426)

摘　　要：目的探讨苗药黑骨藤配伍金铁锁不同极性溶剂提取物的镇痛、抗炎活性。方法采用热板法和醋酸扭体法进行镇痛实验,采用二甲苯致小鼠耳肿胀实验,对黑骨藤配伍金铁锁的水提取物、70%乙醇提取物进行镇痛和抗炎作用实验研究。结果黑骨藤配伍金铁锁水提取物能提高小鼠痛阈值,对醋酸致小鼠扭体反应有一定抑制作用,对二甲苯致小鼠耳廓肿胀也具抑制作用;两药配伍的70%乙醇提取物显著提高小鼠痛阈值,对醋酸致小鼠扭体反应具显著抑制作用,对二甲苯致小鼠耳廓肿胀有明显抑制作用。结论在相同剂量下,黑骨藤配伍金铁锁70%乙醇提取物的镇痛抗炎作用显著优于水提取物的镇痛抗炎作用。Objective To evaluate the anti - inflammatory and analgesic effects of different extracts from the compatibility of Miao medicinal herbs Psamrnosilene tunicoides and Periploca forrestii. Methods The analgesic effect was investigated through the hot plate test and acetic acid writhing test in mice, the anti - inflammatory effect was investigated through xylene - induced auricle tumefaction, samples were extracted from the compatibility of Miao medicinal herbs Psammosilene tunicoides and Periplocaforrestii with 70% alcohol or water. Results Water extract from the compatibility of Psammosilene tunicoides and Periplocaforrestii can in- crease the pain threshold in mice, acetic acid - induced writhing have some inhibitory effect, and also have inhibitory effects on xy- lene - induced ear edema in mice. 70% alcohol extract significantly increased the pain threshold, acetic acid - induced writhing have significant inhibitory effect, and significant inhibitory effects on xylene - induced ear edema in mice. Conclusion In the same dose, anti - inflammatory and analgesic effects of 70% ethanol extract from the compatibility of Miao medicinal herbs Psam- mosilene tunicoides and Periploca forrestii significantly better than the water extract.

关 键 词：黑骨藤配伍金铁锁 提取物 镇痛作用 抗炎作用 

分 类 号：R285.5[医药卫生—中药学]