再生丝素蛋白-羟丙基壳聚糖静电纺纤维毡的研究  

Study on the Electrospun Regenerated Silk Fibroin-Hydroxypropyl Chitosan Mats

作　　者：蔡雯[1] 顾逸[1] 张耀鹏[1] 邵惠丽[1] 

机构地区：[1]东华大学材料科学与工程学院 纤维材料改性国家重点实验室,上海201620

出　　处：《合成纤维》2014年第11期27-31,共5页Synthetic Fiber in China

基　　金：国家自然科学基金项目(21274018;50803011;81170641);上海市教育委员会科研创新项目(12ZZ065);上海市青年科技启明星计划(12QA1400100);中央高校基本科研业务费专项资金资助

摘　　要：采用静电纺丝方法制备了再生丝素蛋白-羟丙基壳聚糖初生纤维毡并对其进行了乙醇后处理。通过扫描电镜、拉曼光谱、X射线衍射及各种性能分析手段研究了初生纤维毡和(或)后处理纤维毡的结构与性能。研究发现:随着羟丙基壳聚糖含量的增多,初生纤维毡中的纤维直径总体有减小的趋势,形貌由圆柱形纤维居多逐渐变成扁带状纤维居多,但仍以无规卷曲/α-螺旋构象和无定形结构为主,而后处理纤维毡的β-折叠构象含量、结晶度和力学性能均呈现先提高后下降的趋势,细胞增殖活性则逐渐增大,生物相容性随之提高。In this paper, regenerated silk fibroin-hydroxypropyl chitosan （RSF-HPCS） composite mats were prepared by electrospinning and then post-treated by ethanol. The structure and properties of the as-spun and （or） post-treated composite mats were characterized by SEM, Raman spectroscopy, XRD and other methods. It was found that with the increase in the content of HPCS, the diameter of as-spun composite fi- bers decreased with the change in morphology from cylinder-like shape to ribbon-like shape. And random coil/a-helix conformation and amorphous structure were still predominant in as-spun mats. On the other hand, with the addition of appropriate amount of HPCS, the post-treated mats showed higher crystallinity and/3-sheet conformation content and their mechanical properties, biocompatibility and proliferation activity were also improved.

关 键 词：丝素蛋白 羟丙基壳聚糖 静电纺丝 共混纤维 

分 类 号：TQ340.64[化学工程—化纤工业]