氯硝安定肌注与灌肠治疗小儿惊厥的价值  

Clinical value of Clonazepam intramuscular injection and enema for infantile convulsion

作　　者：华苏米 丁振尧 余宇龙 卢立党 郭爱红 潘知焕 

机构地区：[1]苍南县人民医院儿科,浙江苍南325800

出　　处：《中国妇幼健康研究》2014年第6期1066-1068,共3页Chinese Journal of Woman and Child Health Research

基　　金：苍南县社会科技基金资助项目(2012S09)

摘　　要：目的 探讨氯硝安定肌注与灌肠在治疗小儿惊厥中的实用价值。方法 收集2012年9月至2013年8月在苍南县人民医院就诊的惊厥患儿120例，随机分为氯硝安定肌注组、苯巴比妥钠肌注组、氯硝安定灌肠组和水合氯醛灌肠组，观察比较各组的疗效及不良反应发生情况。结果 氯硝安定肌注组总有效率（90．00％）高于苯巴比妥钠肌注组（63．33％），差异具有统计学意义（χ^2=4．565，P＜0．05）；氯硝安定灌肠组总有效率（90．00％）高于水合氯醛灌肠组（60．00％）（χ^2=5．689，P＜0．05）；氯硝安定肌注组与灌肠组24 h内均未见惊厥复发，苯巴比妥钠组8例复发，水合氯醛组10例复发；4组用药后均无呼吸抑制、循环障碍等不良反应发生。结论 氯硝安定肌注、灌肠能有效及时控制惊厥，临床推广应用价值显著。Objective To investigate the clinical value of Clonazepam intramuscular injection and enema for infantile convulsion .Methods From September 2012 to August 2013, 120 cases of convulsion visiting the People ’ s Hospital of Cangnan County were collected and randomly divided into 4 groups, Clonazepam intramuscular injection group , Phenobarbital intramuscular injection group , Clonazepam enema group, and 10%chloral hydrate enema group .The curative effect and adverse reactions of each group were observed .Results The total effective rate of Clonazepam intramuscular injection group （90.00%） was significantly higher than that of Phenobarbital intramuscular injection group （63.33%） （χ^2=4.565,P〈0.05）.The total effective rate of Clonazepam enema group （90.00%） was significantly higher than that of chloral hydrate enema group （60.00%） （χ^2=5.689,P〈0.05）.No seizure relapsed in Clonazepam intramuscular injection group and Clonazepam enema group within 24h, but there were 8 cases and 10 cases in Phenobarbital intramuscular injection group and chloral hydrate group , respectively .Respiratory depression , circulatory disorder and other adverse reactions were not found in four groups.Conclusion Clonazepam intramuscular injection and enema can effectively control seizure in time , which has significant clinical value .

关 键 词：小儿 惊厥 氯硝安定 临床价值 

分 类 号：R725[医药卫生—儿科]