γ干扰素在特发性肺纤维化中的相关研究进展  

Research progress on roles of interferon-γ in idiopathic pulmonary fibrosis

作　　者：周雪[1,2] 谢书阳[1] 吕长俊[2] 

机构地区：[1]滨州医学院生化教研室,烟台264003 [2]滨州医学院附属医院呼吸内科,256600

出　　处：《国际呼吸杂志》2014年第24期1882-1885,共4页International Journal of Respiration

摘　　要：特发性肺纤维化是一种病因不明、发病机制不清、缺乏有效治疗手段的弥漫性肺间质疾病,以肺泡上皮损伤、成纤维细胞灶形成、细胞外基质积聚,最终导致肺泡结构异常重塑为病理特征.研究发现,γ干扰素（IFN-γ）能够通过调控信号通路、调控miRNA表达、调节血管再生等发挥抗肺纤维化作用.另有文献报道,IFN-γ可能具有致炎致纤维化的作用.本文针对内源性IFN-γ在特发性肺纤维化发病过程中的作用进行综述,为特发性肺纤维化的发病和治疗提供理论依据.Idiopathic pulmonary fibrosis （IPF） is a diffuse interstitial lung disease with unknown etiology and elusive pathogenesis,and no effective therapy has been shown to stop the progression of IPF.Pathologically,it is characterized by alveolar epithelial injury,fibroblast foci formation and extracellular matrix accumulation,which eventually leads to abnormal alveolar structure disorder and remodeling.It was reported that interferon-γ （IFN-γ） could repress the progression of IPF through regulating angiogenesis,the expression of miRNA and its related genes,and several important signaling pathways.However,some studies also uncovered that IFN-γ might induce the inflammation and fibrosis.Therefore,this paper reviews the roles of endogenous IFN-γ in the pathogenesis of IPF,which provides theoretical foundation for the etiology and therapy of IPF.

关 键 词：Γ干扰素 特发性肺纤维化 信号通路 血管再生 

分 类 号：R563.9[医药卫生—呼吸系统]