帕瑞昔布钠术前用药对乳腺切除术患者血清IL-6及术后镇痛的影响  

Effects of preoperative parecoxib on interleukin 6 and postoperative analgesia for mastectomy

作　　者：滕培兰[1] 徐德荣[1] 杨洁[1] 李奉通 江晨[1] 

机构地区：[1]江苏省连云港市赣榆县人民医院麻醉科,222111

出　　处：《临床麻醉学杂志》2014年第12期1221-1222,共2页Journal of Clinical Anesthesiology

摘　　要：目的：观察帕瑞昔布钠术前用药对乳腺切除术患者血清 IL-6及术后镇痛的影响。方法选择乳腺癌行乳腺切除手术患者60例，随机分为帕瑞昔布钠（P 组）和对照组（C 组），每组30例。所有患者均行静吸复合全身麻醉。P 组于麻醉诱导前10 min 静注帕瑞昔布钠40 mg，C 组静注生理盐水5 ml。术后两组均行静脉自控镇痛（PCIA）。记录术后2、4、8、12、24 h 的疼痛 VAS 评分。采用 ELISA 法测定诱导前10 min、术后4、8和24 h 的血清 IL-6浓度。结果术后2～12 h P 组VAS 评分均明显低于 C 组（P＜0.05）。与诱导前10 min 比较，术后4～24 h 两组血清 IL-6浓度均明显升高（P＜0.01），但 P 组明显低于 C 组（P＜0.01）。结论帕瑞昔布钠术前用药可改善乳腺切除术患者术后镇痛效果，减少血清 IL-6的产生。Objective To investigate the effects of preoperative parecoxib on the levels of inter-leukin 6 （IL-6）and postoperative analgesia for breast surgery.Methods Sixty breast cancer patients undergoing mastectomy were randomly divided into two groups：parecoxib group （group P）and con-trol group （group C）,n=30 in each group.All patients received sevoflurane and fentanyl anesthesia. Group P was injected parecoxib 40 mg at 10 minutes before induction of anesthesia,meanwhile group C was injected saline 5 ml.All patients received postoperative patient-controlled intravenous analgesia （PCIA）with fentanyl.VAS scores for pain were assessed at postoperative 2,4,8,12,24 hours. The serum levels of IL-6 were measured by ELISA at 10 minutes before induction,4 h,8 h,and 24 h after surgery.Results Group P had lower VAS scores than group C at 2-12 h after surgery （P 〈0.05）.Compared with 10 minutes before induction,the levels of IL-6 increased significantly at post-operative 4,8,24 h in two groups （P〈0.01）,while group P had lower levels of IL-6 than group C （P 〈0.01）.Conclusion Preoperative administration of parecoxib has a stronger analgesic effect in breast cancer patients after mastectomy,and decreases the levels of IL-6.

关 键 词：帕瑞昔布 乳腺癌 疼痛 白细胞介素-6 

分 类 号：R614[医药卫生—麻醉学]