化学拆分法制备D-2-氨基丁醇  

Chemical Resolution Method of Synthesis of D-2-amino-butanol

作　　者：臧力[1] 于荣华[1] 乔浩[1] 刘存礼[1] 

机构地区：[1]南京工业大学生物与制药工程学院,江苏南京211816

出　　处：《广州化工》2014年第24期82-84,113,共4页GuangZhou Chemical Industry

摘　　要：以酒石酸为拆分剂,从外消旋2-氨基丁醇中拆分出(D)-2-氨基丁醇和(L)-2-氨基丁醇。考察了不同的溶剂对2-氨基丁醇拆分的影响,最终选取了正丁醇作为拆分溶剂。并对反应时间,反应温度,溶剂体积对拆分的影响进行了考察。在最优条件下,D-2-氨基丁醇的总收率达到83.69%,旋光达到9.9°。D-2-amino-butanol and L-2-amino-butanol were separated from the DL-2-amino-butanol by the tartaric acid as the resolving agent. The effects of different solvent on the separation of 2-amino-butanol were investigated. Finally, butyl alcohol was chosen as the split solvent. The effects of reaction time, reaction temperature, and volume of solvent were also investigated. Under the optimized conditions, the final yield of D-2-amino-butanol was 83. 69% and polarimetry was 9. 9 °.

关 键 词：2-氨基丁醇 酒石酸 旋光 拆分 

分 类 号：TQ463[化学工程—制药化工]