慢性高原病的脑磁共振弥散张量成像研究  

Application of the diffusion tensor imaging in chronic mountain sickness

作　　者：任方远[1] 蔡琳[2] 王悦 刘光耀[1] 郝晓东[1] 高崎炜[1] 

机构地区：[1]兰州军区兰州总医院影像诊断科,甘肃兰州730050 [2]兰州军区兰州总医院信息科 [3]武警甘肃总队医院妇产科

出　　处：《西北国防医学杂志》2014年第4期308-310,共3页Medical Journal of National Defending Forces in Northwest China

基　　金：甘肃省自然科学基金资助项目(145RJZA081)

摘　　要：目的:应用3.0T磁共振弥散张量成像(diffusion tensor imaging,DTI)技术,评价慢性高原病患者脑白质的各向异性分数(fractional anisotrophy,FA)。方法:本研究共包括9例慢性高原病患者和10例正常志愿者,行常规MRI扫描及DTI扫描,测定DTI图像上不同脑白质区的FA值,并比较两组FA值的差异。结果:两组常规MR检查未见明确差异,DTI示慢性高原病组双侧额叶及海马旁白质、胼胝体膝部FA值较正常志愿者组降低,差异具有统计学意义(P<0.05)。结论:慢性高原病患者部分脑白质区FA值下降,提示脑白质纤维束完整性受损。Objective：To evaluate the fractional anisotrophy（FA）value of white matter in patients with chronic mountain sickness（CMS）with diffusion tensor imaging（DTI）on 3.0TMR.Methods：Ten normal controls（NC）and nine patients with CMS underwent conventional MRI and DTI.FA values were measured in different brain regions and then were compared between the two groups.Results：FA value decreased in both sides of the white matters of frontal lobe and parahippocampal gyrus,genu of corpus callusum in patients with CMS in contrast with NC.Conclusion：FA value of a part of white matter decreased,indicating the impairment of the microstructure of the white matter integrity in CMS.

关 键 词：磁共振成像 认知障碍 慢性高原病 

分 类 号：R445.2[医药卫生—影像医学与核医学]