甲基丙烯酸缩水甘油酯交联壳聚糖/聚乙烯醇水凝胶薄膜的制备及性能  

Preparation and Properties of Chitosan/poly(vinyl alcohol)Hydrogel Membrane by Using Glycidyl Methacrylate as Cross-linking Agent

作　　者：饶思奇 回琳 邓敏[1] 徐祖顺[1] 张全元[1] 

机构地区：[1]湖北大学材料科学与工程学院,湖北武汉430062 [2]华中农业大学动物医学院,湖北武汉430070

出　　处：《材料科学与工程学报》2014年第4期543-547,562,共6页Journal of Materials Science and Engineering

摘　　要：以甲基丙烯酸缩水甘油酯(GMA)为交联剂制备了一系列壳聚糖(CS)/聚乙烯醇(PVA)水凝胶薄膜,研究了GMA用量对水凝胶样品溶胀性能、力学性能、热失重、生物相容性以及降解性能等方面的影响。实验表明,制备出的水凝胶薄膜韧性由未加交联剂时的14%增加到300%左右。耐溶剂性能和溶胀能力随交联剂用量增加而先减小后增大,在GMA用量为5%时最优。另外,MTT分析和溶菌酶降解实验表明水凝胶薄膜具有良好的生物相容性和降解性。A series of chitosan （CS）/poly （vinyl alcohol） （PVA） hydrogel memhrane were prepared by using glycidyl methacrylate （GMA） as cross-linking agent. The toughness of the CS/PVA hydrogel membrane was increased from 14% obtained without GMA to about 300% by the GMA cross linking. As GMA content increased, however, swelling properties and 75% ethanol resistance of the prepared CS/PVA hydrogels decreased first, then increased. The CS/PVA hydrogels exerted minimal cytotoxicity toward Caco-2 cells. MTT tests and lysozyme degradat.ion studies suggested that the CS/PVA hydrogel membrane have good biocompatibility and degradability.

关 键 词：壳聚糖 聚乙烯醇 甲基丙烯酸缩水甘油酯 水凝胶薄膜 

分 类 号：TQ320.721[化学工程—合成树脂塑料工业]