宁夏地区变应性鼻炎与微量元素的相关性研究  

The correlation of allergic rhinitis and trace elements in Ningxia region

作　　者：马瑞霞[1] 申月玲 侯丽[1] 杨志超[1] 冯宁宇[1] 闫小会[1] 邵辉[1] 高小平[1] 底玲玲[1] 

机构地区：[1]宁夏医科大学总医院耳鼻咽喉头颈外科,银川750004 [2]河北省唐山迁安市人民医院耳鼻喉科

出　　处：《中华耳鼻咽喉头颈外科杂志》2014年第12期1017-1020,共4页Chinese Journal of Otorhinolaryngology Head and Neck Surgery

基　　金：国家自然科学基金（81260157）;宁夏回族自治区科技攻关资助项目（102164139）

摘　　要：目的 探讨宁夏地区变应性鼻炎（allergic rhinitis,AR）与微量元素的关系,为AR的预防和诊治提供参考.方法 将2010年1-12月就诊于宁夏医科大学总医院诊断为AR的患者106例作为试验组,其中常年性AR 48例,季节性AR 58例,并以健康志愿者103例作为对照组.抽取所有研究对象静脉血3 ～5 ml,采用电感耦合等离子体原子发射光谱（ICP-AES）法测定入选对象血清中微量元素Ca、Ni、Fe、Mg、Zn、Sr、Mn、Cu、Se的含量;剪取AR患者及健康志愿者头发少许,采用上述方法检测相关微量元素的含量,以SPSS 16.0软件进行统计学分析,采用t检验分别比较AR组与健康对照组,常年性AR组与季节性AR组血清及头发中微量元素的差异.结果 AR组血清中Zn、Se的含量分别为（793.48±46.88）、（84.25±12.77） μg/L,低于对照组的（908.53±31.26）、（98.35±15.21） μg/L,差异有统计学意义（t值分别为-24.175、-7.797,P值均＜0.05）;AR组血清中Cu、Ni含量分别为（1 002.18±104.62） μg/L、（21.58±5.54） mg/L,高于对照组的（832.78±50.45） μg/L、（17.04±4.93） mg/L,差异有统计学意义（t值分别为15.545、5.154,P值均＜0.05）.AR组头发中Zn、Se的含量分别为（92.16±4.54）、（0.28±0.04） μg/g,低于对照组的（189.09±8.45）、（0.39±0.06） μg/g,差异有统计学意义（t值分别为-28.71、-8.633,P值均＜0.05）;AR组头发中Cu、Ni含量分别为（42.43±5.03）、（31.72±5.49）μg/g,高于对照组的（23.00±4.45）、（8.94±7.53） μg/g,差异有统计学意义（t值分别为-8.633、4.236,P值均＜0.05）.常年性与季节性AR患者血清微量元素含量差异无统计学意义（P值均＞0.05）.结论 AR患者血清微量元素Zn、Se低于健康对照组中的含量,而Cu、Ni高于健康对照组.常年性AR患者与季节性AR患者血清中微量元素含量无明显差异.Objective To investigate the correlation of allergic rhinitis and trace elements and to provide a reference for clinical diagnosis,treatment and prevention of allergic rhinitis.Methods One hundred and six patients were diagnosed as allergic rhinitis in General Hospital of Ningxia Medical University between January and December in 2010,including 48 cases of perennial allergic rhinitis and 58 cases of seasonal allergic rhinitis.In the same time,one hundred and three healthy volunteers were selected as control.Intravenous blood 3-5 ml were obtained from all subjects both in experimental group and in control group.The content of Ca,Ni,Fe,Mg,Zn,Sr,Mn,Cu,Se in serum and hair was determined by inductively coupled plasma atomic emission spectrometry （ICP-AES）.The t-test （SPSS 16.0） was used to compare the results of trace elements in serum between allergic rhinitis and control group.Results The testing results of trace elements in AR patients serum and normal controls serum were as follows：Cu,Ni （1 002.18 ± 104.62） μg/L,（21.58 ± 5.54） mg/L were super than control group,（832.78 ± 50.45） μg/L,（17.04 ±4.93） mg/L（t value was 15.545,5.154,both P ＜0.05）.But the content of Zn,Se （793.48 ± 46.88） μg/L,（84.25 ± 12.77） μg/L lower than control group （908.53 ± 31.26） μg/L,（98.35 ± 15.21） μg/L （t value was-24.175 and-7.797,both P ＜0.05）.The testing results of trace elements in AR patients hair and normal controls hair were as follows：Cu,Ni （42.43 ± 5.03） μg/g,（31.72±5.49） μg/g were super than control group,（23.00±4.45） μg/g,（8.94±7.53） μg/g （t value was-8.633 and 4.236,both P ＜ 0.05）.But the content of Zn,Se （92.16 ± 4.54） μg/g,（0.28 ±0.04） μg/g lower than control group （189.09 ± 8.45） μg/g,（0.39 ± 0.06） μg/g （t value was-28.71 and-8.633,both P ＜ 0.05）.Conclusions The content of Zn,Se in AR patients serum are lower than that in control group.But the content of Cu,Ni in AR patients serum are super than that

关 键 词：鼻炎 变应性 常年性 鼻炎 变应性 季节性 痕量元素 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]