Structures and Antiviral Activities of Butyrolactone Derivatives Isolated from Aspergillus terreus MXH-23  

作　　者：MA Xinhua ZHU Tianjiao GU Qianqun XI Rui WANG Wei LI Dehai 

机构地区：[1]Key Laboratory of Marine Drugs of Chinese Ministry of Education,School of Medicine and Pharmacy,Ocean University of China [2]Zhangqiu Maternity and Child Health Care Hospital

出　　处：《Journal of Ocean University of China》2014年第6期1067-1070,共4页中国海洋大学学报（英文版）

基　　金：supported by National Natural Science Foundation of China (Nos.41176120 and 30973627);the National High Technology Research and Development Program of China (No.2013AA092901);the Program for New Century Excellent Talents in University (No.NCET12-0499);Promotive Research Fund for Excellent Young and Middle-Aged Scientists of Shandong Province (BS 2010HZ027);the Public Projects of State Oceanic Administration (No. 2010418022-3);the Program for Changjiang Scholars and Innovative Research Team in University (No.IRT0944)

摘　　要：A new butyrolactone derivative,namely butyrolactone Ⅷ （1）,and six known butyrolactones （2-7） were separated from the ethyl acetate （EtOAc） extract of the fermentation broth of a fungus,Aspergillus terreus MXH-23.The chemical structures of these metabolites were identified by analyzing their nuclear magnetic resonance （NMR） and mass spectrometry （MS）.Known butyrolactone derivatives contain an α,β-unsaturated γ-lactone ring with α-hydroxyl and y-benzyl,and butyrolactone Ⅷ （1） was the first butyrolactones contains α-benzyl and γ-hydroxyl on α,β-unsaturated lactone ring.All of the butyrolactone derivatives were tested for their anti-influenza （H 1N 1） effects.Derivatives 4 and 7 showed moderate antiviral activities while the newly-identified,derivative 1,did not.A new butyrolactone derivative, namely butyrolactone VIII(1), and six known butyrolactones(2-7) were separated from the ethyl acetate(Et OAc) extract of the fermentation broth of a fungus, Aspergillus terreus MXH-23. The chemical structures of these metabolites were identified by analyzing their nuclear magnetic resonance(NMR) and mass spectrometry(MS). Known butyrolactone derivatives contain an α,β-unsaturated γ-lactone ring with α-hydroxyl and γ-benzyl, and butyrolactone VIII(1) was the first butyrolactones contains α-benzyl and γ-hydroxyl on α,β-unsaturated lactone ring. All of the butyrolactone derivatives were tested for their anti-influenza(H1N1) effects. Derivatives 4 and 7 showed moderate antiviral activities while the newly-identified, derivative 1, did not.

关 键 词：sponge-derived fungus  secondary metabolite  butyrolactone  anti-influenza activity 

分 类 号：Q936[生物学—微生物学]