温州地区汉族人群CYP2C19和CYP2C9基因多态性分析  

Analysis of genetic polymorphism of CYP2C19 and CYP2C9 in Wenzhou Han population

作　　者：周怀彬[1] 王金丹[1] 胡理怀[1] 温超玮 吕建新[1] 

机构地区：[1]温州医科大学检验医学院,生命科学学院,浙江省医学遗传学重点实验室,浙江温州325035

出　　处：《温州医学院学报》2014年第12期864-867,共4页Journal of Wenzhou Medical College

基　　金：国家青年科学基金资助项目(81200253);浙江省重点科技创新团队资助项目(2012R10048)

摘　　要：目的:研究温州地区汉族人群CYP2C19、CYP2C9基因多态性分布。方法:采用聚合酶链式反应和测序方法,对287例健康人群CYP2C19、CYP2C9基因多态性进行分析。结果:温州地区汉族人群的CYP2C19*1、CYP2C19*2和CYP2C19*3三种等位基因的频率分别为65.16%、29.27%和5.57%;CYP2C19*1/*1、CYP2C19*1/*2、CYP2C19*1/*3、CYP2C19*2/*3、CYP2C19*2/*2和CYP2C19*3/*3基因型的频率分别为44.95%、33.45%、6.97%、4.18%、10.45%和0.00%,弱代谢率为14.63%;CYP2C9*1和CYP2C9*3等位基因频率分别为97.74%和2.26%,CYP2C9*1/*1和CYP2C9*1/*3的基因频率为95.47%和4.53%,未发现CYP2C9*3/*3。结论:温州地区汉族人群CYP2C19和CYP2C9弱代谢率与已报道的汉族人群基本一致,与日本人群相近,显著高于欧美人群。Objective： To investigate distribution status of CYP2C19 and CYP2C9 genotype in Wenzhou Han population. Methods： The CYP2C19 and CYP2C9 genotype of 287 Wenzhou Han Chinese were determined by sequencing. Results： In Wenzhou Han population, CYP2C19＊1, CYP2C19＊2 and CYP2C19＊3 allele frequencies were 65.16%, 29.27% and 13.6%, respectively; CYP2C19＊1/＊1, CYP2C19＊1/＊2, CYP2C19＊1/＊3, CYP2C19＊2/＊3, CYP2C19＊2/＊2 and CYP2C19＊3/＊3 genotype frequencies were 44.95%, 33.45%, 6.97%, 4.18% and 0.00%, respectively. The frequency of CYP2C19 poor metabolisms was 14.63%; CYP2C9＊1 and CYP2C9＊3 allele frequencies were 97.74% and 2.26%, respectively; CYP2C9＊1/＊1 and CYP2C9＊1/＊3 genotype frequencies were 95.47% and 4.53%, respectively, CYP2C9＊3/＊3 homozygous genotype was not found in this study. Conclusion： The frequencie of CYP2C19 and CYP2C9 poor metabolisms are similar to those of Japanese population, whereas they are significantly different from America-European populations.

关 键 词：P450 CYP2C19 CYP2C9 多态性 温州地区 汉族 

分 类 号：Q39[生物学—遗传学] R969.3[医药卫生—药理学]