仙台病毒抗肿瘤的研究进展  

Research Progress on Sendai Virus against Tumors

作　　者：张泉[1] 朱慧霞[1] 李翎瑜 谭海明[1] 薛整风[1] 

机构地区：[1]扬州大学兽医学院比较医学中心,扬州225009

出　　处：《实验动物与比较医学》2014年第6期515-518,共4页Laboratory Animal and Comparative Medicine

基　　金：国家自然科学基金（31302042）,江苏省自然科学基金（BK20130045）

摘　　要：仙台病毒是实验大、小鼠的常见病原之一.大、小鼠感染仙台病毒后,可通过诱生Ⅰ型干扰素、调节免疫应答和致肿瘤细胞凋亡等干预肿瘤生长,该病毒已逐渐被开发为一种新型、高效的抗肿瘤制剂.本文综述了仙台病毒抗肿瘤、对科学研究的干扰作用等方面进展.Sendai virus is one of the common pathogens in laboratory rats and mice.Transplanted tumors may be inhibited by type I interferon induction,immune response regulation and directly apoptosis in cancer cells after Sendai virus infection in hosts.Nowadays,Sendai virus has already been gradually developed as an effective and new anti-cancer reagent.In this review,the mechanisms of Sendai virus infection against cancer growth and interference on experiment were described.

关 键 词：仙台病毒(SeV) 肿瘤 干扰素 免疫调节 凋亡 

分 类 号：Q95-33[生物学—动物学]