前列地尔注射液治疗HBV相关性慢性淤胆型肝炎疗效观察  

The clinical effect of alprostadil injection on patients with HBV related chronic cholestatic hepatitis

作　　者：陈文[1] 杨春[2] 唐黎[1] 

机构地区：[1]泸州医学院附属医院感染科,四川泸州646000 [2]泸州医学院附属医院消化内科,四川泸州646000

出　　处：《西部医学》2015年第1期75-77,共3页Medical Journal of West China

摘　　要：目的研究前列地尔注射液对乙型肝炎病毒(HBV)感染后慢性淤胆型肝炎患者的临床疗效。方法收集HBV相关性慢性淤胆型肝炎患者116例,分对照组52例,前列地尔注射液治疗组64例。观察治疗前后两组患者血清转氨酶、总胆红素(TBIL)、γ-谷氨酰转肽酶(γ-GT)和碱性磷酸酶(ALP)变化;分析临床有效率并观察药物不良反应。结果前列地尔注射液治疗4周时丙氨酸氨基转氨酶(ALT)、天门冬氨基转移酶(AST)、TBIL、γ-GT和ALP均显著下降,且下降程度比对照组更为明显,差异有统计学意义(P<0.05)。治疗组有效率显著高于对照组,差异有统计学意义(76.56%vs.55.77%,P=0.028)。结论前列地尔注射液治疗HBV相关性慢性淤胆型肝炎有较好的临床效果和安全性。Objective To investigate the clinical effect of alprostadil injection on patients with HBV related chronic chotestatic hepatitis. Methods 116 patients with HBV related chronic cholestatic hepatitis were divided into treatment group （n= 64） administration with alprostadil injection and control group （n= 52）. The changes of aminotransferase, total bilirubin （TBIL）, 7-glutamyl transpeptidas （y-GT）, and alkaline phosphatase （ALP） were measured by automatic biochemical analyzers. The effective rate and side-effected of alprostadil were analyzed. Results The level of alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, TBIL, γ-GT, and ALP were significant decreased in both of the two groups （P〈0.05）. The changes of the ALT, AST, TBIL, γ-GT, and ALP were significant higher in treatment group than that of control group （P〈0.05）. There was significant deference in effective rate between the treatment group and control group （76.56%vs. 55.77%, P=0. 028）. Conclusion Alprostadil injection is safe and effective to the patients with HBV related chronic cholestatic hepatitis.

关 键 词：前列地尔 乙型肝炎病毒 慢性淤胆型肝炎 疗效 

分 类 号：R512.6[医药卫生—内科学]