银杏叶提取物对改善早期糖尿病肾病患者内皮功能的临床观察  

Ginko biloba extract improves endothelial function in patients with early diabetic nephropathy

作　　者：刘滇军[1] 刘辉辉[1] 李骏峰[1] 沈建明[1] 田少江[1] 王黎萍[1] 

机构地区：[1]湖北医药学院附属人民医院肾内科,湖北十堰442000

出　　处：《西部医学》2015年第1期80-82,共3页Medical Journal of West China

摘　　要：目的探讨银杏叶提取物(ginko biloba extract,GBE)对早期糖尿病肾病(diabetic nephropathy,DN)患者内皮功能的影响及其作用机制。方法将62例DN患者随机分为两组,对照组仅行常规降糖治疗,治疗组在常规降糖治疗基础上加用GBE治疗。疗程12周,早期比较两组患者治疗前后肱动脉内皮依赖性血管舒张功能(endothelium dependent dilation,EDD)、血管性假性血友病因子(vWF)、血清一氧化氮(NO)、超氧化物歧化酶(SOD)、丙二醛(MDA)、24小时尿微量白蛋白排泄量(UAE)变化。结果治疗组治疗后EDD上升、vWF下降、NO升高,氧化应激水平降低,UAE明显下降,与治疗前及对照组治疗后相比差异均有统计学意义(P<0.05);对照组上述指标治疗前后无显著变化(P>0.05)。结论 GBE通过降低早期DN患者的氧化应激水平来改善患者内皮功能,并明显降低患者的UAE,从而延缓早期DN的进展。Objective To discuss the effect and mechanism of ginko biloba extract （GBE） on endothelial function in patients with early diabetic nephropathy （DN）. Methods 62 patients with early DN were randomly divided into the control and treatment group. All the patients were given treatment to control blood glucose and 31 patients in the treatment group were treated with GBE for 12 weeks. Endothelium dependent dilation （EDD）, plasma levels of vWF, serum nitric oxide（NO）, serum superoxide dismutase （SOD）, malondialdehyde （MDA） and urinary albumin excretion （UAE） were detected before and after the treatment. Results After 12 weeks of treatment, the levels of EDD in the treatment group were significantly increased, while plasma levels of vWF were significantly decreased. The levels of NO were increased, while the levels of oxidative stress were ameliorated （P〈0.05）,and the levels of UAE were significantly decreased（P〈 0.01）. Compared with the control group, after the treatment, the above mentioned indexes were ameliorated significantly in the treatment group （P〈0.05）. The levels of EDD, vWF,NO, SOD, MDA and UAE had no changes after the treat ment in the control group （P〉0.05）. Conclusion The treatment of GBE in early DN patients can significantly improve endothelial function and decrease the level of UAE and postpone the development of DN, which may be due to its im- provement of oxidative stress.

关 键 词：银杏叶提取物 糖尿病肾病 内皮功能 氧化应激 

分 类 号：R587.1[医药卫生—内分泌]