孟鲁司特联合沙丁胺醇气雾剂治疗对咳嗽变异性哮喘白细胞介素-6、肿瘤坏死因子-α影响  

Influence of interleukin-6,tumor necrosis factor-αand clinical efficacy for montelukast combined with salbutamol aerosol treatment in cough variant asthma

作　　者：朱明辉[1] 胡广奋[1] 陆婉晖[1] 黎靖麟[2] 

机构地区：[1]广州市第一人民医院鹤洞分院内科,广东广州510380 [2]广州市第一人民医院急诊科,广东广州510180

出　　处：《临床荟萃》2015年第1期54-56,共3页Clinical Focus

摘　　要：目的探讨孟鲁司特联合沙丁胺醇气雾剂治疗咳嗽变异性哮喘的临床疗效。方法选取128例咳嗽变异性哮喘患者,随机分为观察组和对照组,对照组仅给予沙丁胺醇气雾剂,观察组采用孟鲁司特联合沙丁胺醇气雾剂治疗,比较两组患者临床疗效、肺功能、咳嗽消失时间及血清细胞因子变化。结果对照组治疗有效率为75.0%,观察组有效率为94.8%,观察组显著优于对照组(P<0.05)。观察组第1秒用力呼气容积(FEV1)、第1秒用力呼气容积/用力肺活量(FEV1/FVC)分别为(2.19±0.16)L、(66.09±4.34)%,对照组FEV1、FEV1/FVC分别为(1.83±0.12)L、(52.15±3.41)%,两组比较差异有统计学意义(t=3.131、4.850,P=0.035、0.008,P<0.05)。观察组血清白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)分别为(14.06±2.94)ng/L、(0.68±0.11)ng/L,对照组血清IL-6、TNF-α分别为(20.91±3.08)ng/L、(0.99±0.13)ng/L,两组比较差异有统计学意义(P<0.05)。对照组患者平均咳嗽消失时间为(6.33±0.58)d,观察组患者平均咳嗽消失时间为(9.33±0.58)d,两组比较差异有统计学意义(P<0.01或<0.05)。结论采用孟鲁司特联合沙丁胺醇气雾剂在治疗咳嗽变异性哮喘安全有效,值得临床推广使用。ABSTRACT：Objective To evaluate the clinical efficacy of montelukast combined with salbutamol aerosol treatment in cough variant asthma.Methods A total of 128 patients with cough variant asthma were randomly divided into control group and observation group,64 cases in each group.Montelukast combined with salbutamol aerosol were used in observation group and salbutamol aerosol alone was used in control group.The clinical efficacy,lung function, cough disappeared time and the changes of serum cytokines were compared between two groups.Results The efficiency of observation group was 94.8%,as compared with that of control group 75.0%,the difference was statistically significant （P 〈0.05）.The FEV1 and FEV1/FVC of observation group were respectively （2.19±0.16） L and （66.09±4.34）%,those of control group （1.83±0.12）L and （52.15±3.41）%,showed significant differences between the two groups（both P 〈0.05）.The serum interleukin-6 （IL-6）and tumor necrosis factor-α（TNF-α）of observation group were （14.06±2.94）ng/L and （0.68±0.11）ng/L,those of control group （20.91±3.08）ng/L and （0.99±0.13）ng/L,showed significant differences between two groups （both P 〈0.05）.The cough disappeared time of observation group was （9.33 ± 0.58）d,that of control group （6.33 ± 0.58）d,showed significant differences between the two groups（P 〈0.01）.Conclusion Montelukast combined with salbutamol aerosol treatment in cough variant asthma is safe and effective,worths clinical promotion.

关 键 词：哮喘 孟鲁司特 沙丁胺醇 

分 类 号：R563[医药卫生—呼吸系统]