大剂量氨溴索联合NCPAP对新生儿呼吸衰竭血浆脑利钠肽水平的影响  

Influence of large doses of ambroxol combined with NCPAP in treatment of neonatal respiratory failure on plasma brain natriuretic peptide levels

作　　者：方平昌 岳海珍 高丽霞 陈玉芬[3] 

机构地区：[1]河北省曲周县医院儿科,057250 [2]石家庄市井陉矿区医院儿科,050100 [3]河北省邯郸市第一医院妇科,056002

出　　处：《临床合理用药杂志》2015年第1期37-38,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察大剂量氨溴索联合鼻塞式气道正压通气(NCPAP)治疗新生儿呼吸衰竭的疗效及对血浆脑利钠肽水平的影响。方法选取2012年4月-2014年8月住院治疗的呼吸衰竭新生儿120例为研究对象,按照患儿家长的治疗意愿分为试验组和对照组各60例。试验组患儿采用大剂量氨溴索联合NCPAP治疗,对照组患儿采用大剂量氨溴索治疗治疗。分析2组患儿的治疗效果、并发症发生率、治疗前后血浆脑利钠肽水平变化。结果试验组患儿总有效率为93.3%高于对照组的76.7%,差异有统计学意义(P<0.05)。治疗前2组血浆脑利钠肽水平比较差异无统计学意义(P>0.05),治疗后2组均降低,且试验组低于对照组,差异均有统计学意义(P<0.05)。试验组患儿并发症发生率为3.3%(2/60)低于对照组的5.0%(3/60),但差异无统计学意义(P>0.05)。结论大剂量氨溴索联合NCPAP治疗新生儿呼吸衰竭效果显著,能有效改善血浆脑利钠肽水平,安全有效,值得临床推广。Objective To observe the influence of large doses of ambroxol combined with NCPAP in treatment of neo-natal respiratory failure on plasma brain natriuretic peptide levels. Methods 120 children with neonatal respiratory failure,se-lected from April 2012 to August 2014 in the hospital,were divided into test group and control group according with the wishes of the parents,each of 60 cases. Test group were treated with high-dose ambroxol combined with NCPAP,control group were treated with high-dose ambroxol treatment. Analyzed treatment effect,the incidence of complications,sodium plasma brain natri-uretic peptide levels of two groups before and after treatment. Results The total effective rate of test group was 93. 3% higher than 76. 7% of control group,the difference was statistically significant（P〈0. 05）. Two groups before treatment plasma brain natriuretic peptide level difference was not statistically significant（P 〉0. 05）. After treatment the brain natriuretic peptide plasma sodium levels two groups were reduced,and test group was lower than control group,the difference was statistically sig-nificance（P〈0. 05）. The complication rate of test group was 3. 3%（2/60）less than 5. 0%（3/60）of control group,the difference was not statistically significant（P〉0. 05）. Conclusion The treatment of large dose ambroxol combined with NC-PAP in neonatal respiratory failure has significant effect,can effectively improve the level of brain natriuretic peptides,safe,ef-fective and worthy of promotion.

关 键 词：新生儿呼吸衰竭 鼻塞式气道正压通气 氨溴索 血浆脑利钠肽 

分 类 号：R722.1[医药卫生—儿科]