IL-17 mRNA在肝脏泡型包虫病中的表达及其临床意义  

Expression of IL-17 mRNA in patients with alveolar echinococcosis and its clinical significance

作　　者：马尔旦.马合木提 吐尔洪江.吐逊 马海长[1] 沙地克.阿帕尔 赵晋明[1] 邰沁文[1] 张金辉[1] 

机构地区：[1]新疆医科大学第一附属医院消化血管外科中心肝脏.腹腔镜外科,新疆乌鲁木齐830054

出　　处：《中国现代普通外科进展》2014年第10期771-774,共4页Chinese Journal of Current Advances in General Surgery

基　　金：新疆维吾尔自治区自然科学基金(青年基金2014211C081)

摘　　要：目的:探讨Th17细胞特异性细胞因子IL-17 m RNA在肝脏泡型包虫病患者肝脏组织中的表达及其临床意义。方法:将14例经手术确诊的肝脏泡型包虫病患者肝脏组织分为3组:病灶组织(L)组,病灶邻近组织(PL)组和正常肝脏组织(N)组。应用实时荧光定量PCR技术检测各组受试者Th17细胞相关细胞因子IL-17 m RNA的表达。结果:IL-17 m RNA水平在L组、PL组和N组分别为(4.920 7±5.386 4)pg/m L(0.234、9±0.417 9)pg/m L和(0.055 7±0.114 9)pg/m L,L组较PL组和N组明显升高(P<0.01);PL组较N组轻度升高,但差异无统计学意义(P>0.05)。结论:IL-17 m RNA在肝泡型包虫病患者肝脏病灶组织中表达显著升高,可能和棘球蚴感染过程中所致免疫损伤和炎性肉芽肿形成有关。Objective：To investigate the expression and clinical significance of the specific cytokine of Th9 cell-lL-17 mRNA in patients with hepatic alveolar echinococcosis.Methods：14 subjects who admitted to our hospital were enrolled and the expressions of IL-17 mRNA from lesion （L）,para-lesion （PL） and normal liver tissues （N） were detected with real-time PCR.For statistical analysis,Student＇s t test were used.Results：Compared with group N and group PL,the expression of IL-17 mRNA in group L was significantly increased with remarkably statistical significance （P＜0.01）.The level of IL-17 mRNA was increased in group PL when comparing with group N,but with no statistical significance （P＞0.05）.Conclusion：Expression of IL-17 mRNA in group L was significantly increased.It can be deduced from this study that Th17 cell may be involved in the progress of immune destruction during the infection of alveolar echinococcosis.

关 键 词：棘球蚴病 肝 TH17细胞 寄生虫感染 免疫损伤 

分 类 号：R657.3[医药卫生—外科学]