生物力学改变法制备膝骨关节炎动物模型研究进展  

Research progress on establishment knee osteoarthritis animal models with biomechanics change method

作　　者：陈世宣 冯伟[1,2] 沈黎辉[1] 顾小华[3] 洪潮[3] 曹欣宇[3] 赵勇[3] 

机构地区：[1]上海市第七人民医院康复医学部,上海200137 [2]上海中医药大学康复医学院,上海201203 [3]上海市第七人民医院骨伤科,上海200137

出　　处：《上海中医药杂志》2014年第12期91-93,共3页Shanghai Journal of Traditional Chinese Medicine

基　　金：上海市科委"上海市浦江人才计划"项目(10PJ1409300);上海市科委自然科学基金项目(09ZR1432000);上海市卫计委第三批中医优势专科(骨伤康复)建设项目(zysnxd-yl-yszk032);上海市浦东新区卫计委资助项目(PW2014A-20);上海市虹口区卫计委资助项目(虹卫:1403-29)

摘　　要：综述近年来有关运用生物力学改变法制备膝骨关节炎动物模型研究的概况。主要包括髌韧带内侧缺损法、髌韧带延长法、Hulth-Telhag法、前交叉韧带切除法、半月板切除法、关节固定法等;认为不同方法制备的动物模型具有不同的特点,且各自具有优缺点和适用范围,应用时宜选择与研究目的相适应的动物模型。This study overviews the use of biomechanical change to prepare knee osteoarthritis animal models in recent years. It includes inside defect of patellar ligament,the extension of patellar ligament,Hulth-Telhag,excision of anterior cruciate ligament,meniscectomy and joint fixation; the author thinks animal models prepared with different methods have different characteristics,and each has advantages,disadvantages and range of application,and those animal models should be chosen according to the research purposes.

关 键 词：生物力学改变 骨关节炎 动物模型 综述 

分 类 号：R684.3[医药卫生—骨科学]