注射用盐酸头孢甲肟与注射用阿昔洛韦的配伍稳定性考察  

Study on the Compatible Stability of Cefmenoxime for Injection with Acyclovir for Injection

作　　者：王建欣[1] 赵梦然[1] 王玲娇[1] 杨继章[1] 

机构地区：[1]河北医科大学第一医院,石家庄050031

出　　处：《中国药房》2015年第2期198-200,共3页China Pharmacy

基　　金：河北省医学科学研究重点课题(No.20120276)

摘　　要：目的:考察注射用盐酸头孢甲肟与注射用阿昔洛韦在0.9%氯化钠注射液和5%葡萄糖注射液中的配伍稳定性。方法:在室温下观察盐酸头孢甲肟与注射用阿昔洛韦配伍后的外观及p H值变化,并采用高效液相色谱法测定两药的含量变化。结果:两药配伍后在6 h内外观及p H值均无明显变化,阿昔洛韦含量均大于97%,但头孢甲肟含量下降至79.41%。结论:注射用盐酸头孢甲肟不能与注射用阿昔洛韦在0.9%氯化钠注射液和5%葡萄糖中配伍使用。OBJECTIVE： To investigate the compatible stability of Cefmenoxime for injection with Acyclovir for injection in 0.9% Sodium chloride injection and 5% Glucose injection. METHODS： At room temperature, the appearance and pH of the mix- tures were observed, and HPLC method was adopted to determine the contents of cefmenoxime and acyclovir after Cefmenoxime for injection combined with Acyclovir for injection. RESULTS： No significant change was noted for the mixture in appearance and pH value within 6h. The content of acyclovir was higher than 97 %, and that of cefmenoxime was higher than 79.41%. CONCLU- SIONS： The mixture is stable at room temperature after Cefrnenoxime for injection is mixed with Acyclovir for injection in Sodium chloride injection and 5% Glucose injection.

关 键 词：头孢甲肟 阿昔洛韦 高效液相色谱法 配伍 稳定性 

分 类 号：R978.1[医药卫生—药品] R969.2[医药卫生—药学]