基于Friedel-Crafts反应的3-吲哚取代苯硼唑的水相合成  

Synthesis of 3-Indolyl-substituted Benzoboroxole via Friedel-Crafts Reaction in Water

作　　者：张慧明[1] 沈少春[1,2] 杨笑迪[3] 孙兴文[1] 

机构地区：[1]复旦大学化学系,上海200433 [2]上海石油化工研究院,上海201208 [3]复旦大学先进材料实验室,上海200433

出　　处：《有机化学》2014年第12期2456-2461,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.20802009;21103023)资助项目~~

摘　　要：报道了一种基于Friedel-Crafts反应的3-吲哚取代苯硼唑的水相合成方法.以邻甲酰苯硼酸和吲哚为原料,无需外加催化剂,在室温下使用纯水为反应介质,以中等到定量的产率得到3-吲哚取代的苯硼唑类化合物.该方法具有操作简单、合成效率高、环境友好的优点.A highly efficient and catalyst free approach for the synthesis of 3-indolyl-substituted benzoboroxole via Friedel-Crafts reaction in water was developed successfully using readily accessible 2-formylbenzeneboronic acid and indole as the starting material and water as solvent at room temperature. An array of desired 3-indolyl-substituted benzoboroxoles was syn-thesized in moderate to near quantitative yield.

关 键 词：FRIEDEL-CRAFTS反应 3-吲哚取代苯硼唑 水相合成 

分 类 号：O627.31[理学—有机化学]