Hedgehog信号通路对胸腺T细胞分化发育的影响  

Roles of Hedgehog signaling in T cell differentiation and development

作　　者：冯小兵[1] 李月敏[1] 李杨[2] 

机构地区：[1]解放军第309医院肿瘤放疗科,北京100091 [2]军事医学科学院放射与辐射医学研究所

出　　处：《国际肿瘤学杂志》2014年第11期813-816,共4页Journal of International Oncology

基　　金：中国博士后科学基金（201003778）

摘　　要：胸腺产生成熟功能性T细胞需要来自胸腺内多种信号如Wnt、Notch及Hedgehog等.Hedgehog家族不仅参与胚胎发育、组织及器官形成,近年来发现其与多种肿瘤的发生有着密切的联系.胸腺T细胞分化发育异常可能会引起各种免疫疾病以及肿瘤的发生.阐明Hedgehog信号通路对胸腺T细胞分化发育的影响对于肿瘤的治疗具有理论指导作用.The production of mature functional T cells requires many signals from the thymus such as Wnt,Notch and Hedgehog,et al.The Hedgehog protein family signals for development,patterning and organogenesis of many tissues during mammalian embryogenesis.In recent years,more and more research groups focus their attention on it because of its relationship between tumors.Abnormal differentiation and development of T cells may cause various immunological diseases and tumors.Illuminating the roles of Hedgehog signaling in T cell differentiation and development can provide a theoretical guide in the treatment of tumor.

关 键 词：T淋巴细胞 胸腺 细胞分化 HEDGEHOG信号通路 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]