血清甲状腺激素NOEGF及免疫球蛋白水平检测在慢性乙肝诊断中的价值  

Diagnosis Value of Serum Thyroid Hormone NO EGF and Immunoglobulin Levels Detected in Chronic Hepatitis B Liver Disease

作　　者：左彦[1] 陈远博[1] 张允健[1] 

机构地区：[1]广东省深圳市宝安区松岗人民医院消化内科,广东深圳518105

出　　处：《河北医学》2015年第1期20-24,共5页Hebei Medicine

基　　金：广东省深圳市科技计划项目;(编号:2011678)

摘　　要：目的:探讨血清甲状腺激素、NO、EGF及免疫球蛋白水平表达在慢性乙型肝炎、乙肝肝硬化患者中表达的意义。方法:选择我院收入的诊断为肝病患者共89例,其中慢性乙型肝炎患者42例,乙肝肝硬化患者47例。随机选择同期正常健康体检者50例作为健康对照组,对比三组血清甲状腺激素、一氧化氮、表皮生长因子及免疫球蛋白水平表达。结果:乙型肝炎组、乙肝肝硬化组EGF、NO表达均高于健康对照组(P<0.05)。乙型肝硬化组EGF、NO表达高于乙肝肝炎组(P<0.05)。乙肝肝硬化组、乙型肝炎组Ig G、Ig A、Ig M浓度显著高于健康对照组(P<0.05)。乙肝肝硬化组Ig G、Ig A显著高于乙型肝炎组(P<0.05)。乙肝肝硬化组、乙型肝炎组患者TT3、TT4、FT3、FT4浓度均低于健康对照组(P<0.05)。乙肝肝硬化组TT3、TT4、FT3、FT4低于乙型肝炎组(P<0.05)。结论:血清甲状腺激素、NO、EGF及免疫球蛋白水平表达可作为检测乙型肝炎、乙肝肝硬化的指标。Objective：To investigate the serum thyroid hormone , NO, EGF and immunoglobulin levels in chronic hepatitis B patients with liver cirrhosis .Method：In our hospital , with a total income of 89 cases diagnosis of liver disease in patients , including 42 patients with chronic hepatitis ,47 cases liver cirrhosis patients.Selected at random in 50 cases of healthy people as a healthy control group , compared the three groups of serum thyroid hormones , nitric oxide , epidermal growth factor and immunoglobulin levels of expres-sion.Result：In three groups of patients with serum EGF , NO concentration changes in expression of con-trast , hepatitis B , hepatitis B and group cirrhosis group EGF , NO expression were higher than that of control group, there was statistically significant difference between the results of comparison , P 〈0.05.In hepatitis B cirrhosis group EGF , NO expression was higher than hepatitis B hepatitis group , there was statistically significant difference between the results , P〈0.05.Patients with different liver diseases in IgG , IgA, IgM con-centration changes in display contrast , liver cirrhosis,hepatitis B group IgG , group IgA, IgM were signifi-cantly higher than those in control group , the results compared with statistical significance , P 〈0.05.Hepa-titis B cirrhosis group were significantly higher than those of IgG , IgA hepatitis group , the results compared with statistical significance , P 〈0.05.In patients with different liver diseases in TT 3, TT4, FT3, FT4, TSH concentration in contrast , liver cirrhosis of hepatitis B patients group , TT3, TT4, FT3, FT4 concentrations were lower than those of the control group , there was statistically significant difference between the results of comparison, P 〈0.05.Hepatitis B cirrhosis group TT3, TT4, FT3, FT4 lower than hepatitis group , there was statistically significant difference between the results of comparison , P 〈0.05.Conclusion：The serum thyroid hormone , NO, EGF and immunoglobulin levels of expression can be used a

关 键 词：血清甲状腺激素 NO 乙型肝炎 乙肝肝硬化 

分 类 号：R512.62[医药卫生—内科学]