运用动态因果模型探究精神分裂症异常有效连接  

Abnormal Effective Connectivity in Schizophrenia: Dynamic Causal Modelling

作　　者：徐静[1,2] 李德民[1] 聂彬彬[2] 王静娟[2] 宋银南 刘哲宁[3] 单保慈[2] 

机构地区：[1]郑州大学物理工程学院,郑州450001 [2]中国科学院高能物理研究所核辐射与核能技术重点实验室,北京100049 [3]中南大学湘雅二医院精神卫生研究所,长沙410011

出　　处：《中国临床心理学杂志》2014年第6期981-984,共4页Chinese Journal of Clinical Psychology

基　　金：国家自然科学基金(81201147)

摘　　要：目的:探讨精神分裂症患者异常的有效连接。方法:对25例精神分裂症患者和27例对照组进行N-back任务下的功能磁共振扫描,采用全脑连接和建立广义线性模型相结合,选取两组间有激活差异且存在连接差异的脑区为感兴趣区,加入到动态因果模型。结果:确定感兴趣区为左侧内侧前额叶、左侧后扣带回和左侧中扣带回,精神分裂症患者和对照组存在相反的有效连接。结论:两种方法结合更加客观的展示了精神分裂症患者前额叶有功能异常,可能与工作记忆下降有关;另存在方向相反的有效连接,提示患者的无意识"经验"存在缺陷,导致对中性事件产生错误的过多的归因。Objective： To investigate abnormal effective connectivity of schizophrenia. Methods： 25 patients with schizophrenia and 27 healthy control subjects were recruited to complete the functional magnetic resonance imaging（fMRI） scanning in an n-back task, whole-brain connection combined generalized linear models to determine the region of interests that have activation difference and connection difference between the two groups, dynamic causal modelling was applied to explore the effective connectivity between two groups. Results： The region of interests were identified as Superior frontal gyrus medial, Posterior cingulate gyrus and Middle cingulate gyrus. Compared with healthy controls group, the schizophrenia patients had opposite effective connectivity. Conclusion： The findings suggest that the prefrontal functional abnormalities may be associated with deficits of working memory in schizophrenia, and that the abnormal effective connectivity may impair patient＇ t unconscious “experience”, finally leading to a neutral event occurs excessive error.

关 键 词：精神分裂症 动态因果模型 感兴趣区 任务态功能磁共振 

分 类 号：R395.1[哲学宗教—心理学]