老年人认知功能减退知情者问卷判断阿尔茨海默病患者严重程度的效度  

Informant Questionnaire on Cognitive Decline in the Elderly for Assessing Severity of Cognitive Impairment in Patients with Alzheimer's Disease

作　　者：刘艳[1,2] 丁云龙[1] 钮佳丽 周燕[2] 郭起浩[2] 

机构地区：[1]靖江市人民医院,靖江214500 [2]复旦大学附属华山医院,上海200040

出　　处：《中国临床心理学杂志》2014年第6期1050-1052,共3页Chinese Journal of Clinical Psychology

摘　　要：目的:评价老年人认知功能减退知情者问卷(IQCODE)区分阿尔茨海默病(AD)患者认知功能损害程度的有效性。方法:收集来院就诊的AD患者332例,按临床痴呆程度标准分为轻、中、重度组,应用简短版本的老年人认知功能减退知情者问卷(IQCODE)对其知情者进行问卷调查。分析各组IQCODE得分与简明精神状态量表(MMSE)、Mattis痴呆评定量表(DRS)、阿尔茨海默病评估量表-认知部分(ADAS-Cog)得分的相关性,检验其区分不同认知功能损害程度的效度。结果:IQCODE与MMSE、DRS、ADAS-cog的相关系数分别为-0.512、-0.478和0.522。以65分作为划界分区分轻-中度痴呆,敏感性为66.9%,特异性为57.3%;以75分作为划界分区分中-重度痴呆,敏感性为73.8%,特异性为66.9%。结论:IQCODE可以中等有效地区分不同程度的认知功能障碍,但单独使用准确性欠佳,建议临床结合其他痴呆量表使用,以提高评定效能。Objective： To evaluate the efficacy of informant questionnaire on cognitive decline in the elderly（IQCODE） in the assessing the severity of cognitive impairment in patients with Alzheimer＇ s disease. Methods： According to the clinical dementia rating, 332 patients with AD were classified into three groups： early, moderate and late stage group. Informants were interviewed with the short version of the IQCODE, which was used to analyse the correlation relationship with the mini-mental state examination（MMSE）, the Mattis dementia rating scale（DRS） and the Alzheimer＇ s disease assessment scale-cognitive subscale（ADAS-cog）. A series of statistical analysis were carried out to measure the differences of IQCODE scores among three groups. Results： The validity coefficient of IQCODE with MMSE, DRS and ADAS-cog were-0.512, - 0.478 and 0.522 respectively. Taking an IQCODE threshold of 65 to discriminate early stage from moderate, the sensitivity was 66.9% and specificity was 57.3% while taking 75 for threshold to discriminate moderate from late, the sensitivity was 73.8% and specificity was 66.9%. Conclusion： IQCODE is moderately effective for assessing severity of cognitive impairment in patients with Alzheimer＇ s disease, but the IQCODE alone would result in misjudgments, and combing with other clinical dementia rating seals is helpful to improve the evaluation efficiency.

关 键 词：老年人认知功能减退知情者问卷 阿尔茨海默病 认知功能损害 

分 类 号：R395.1[哲学宗教—心理学]