侵袭性肺曲霉病的临床特征分析  

Clinical Manifestations and Imaging Findings of Patients with Invasive Pulmonary Aspergillosis

作　　者：刘丹丹[1,2] 陈慧[3] 邵长周[1] 何礼贤[1] 

机构地区：[1]复旦大学附属中山医院呼吸科,上海200032 [2]安徽省第二人民医院呼吸科,安徽合肥230041 [3]浙江省金华市中心医院呼吸科,浙江金华321000

出　　处：《中国临床医学》2014年第5期540-542,共3页Chinese Journal of Clinical Medicine

基　　金：上海市自然科学基金项目(编号:13ZR1406600);浙江省金华市科学技术局社发重点计划项目(编号:2011-3-002)

摘　　要：目的:探讨侵袭性肺曲霉病(invasive pulmonary aspergillosis,IPA)的临床特征。方法:回顾分析83例IPA患者的临床及影像学资料。结果:IPA患者的主要临床表现为发热、咳嗽、咳痰、喘息、呼吸困难、咯血。IPA患者的影像学表现多样,典型表现如晕征和新月征则较少见(主要见于免疫抑制患者)。83例中原发性IPA患者18例,均治愈;继发性IPA患者65例,治愈23例,好转出院25例,患者要求出院12例,病死5例。结论:IPA好发于有基础疾病和免疫抑制的患者,其临床和影像学表现不典型;原发性IPA较继发性IPA预后好。Objective：To investigate the clinical features of invasive pulmonary aspergillosis （IPA）.Methods：The clinical fea-tures and imaging characteristics of 83 patients with IPA were retrospectively and comparatively analyzed.Results：The clinical manifestations of IPA included fever,cough,sputum,wheezing,dyspnea,hemoptysis.Imaging findings in patients with IPA were diverse.Typical manifestations such as Halo sign and crescent sign were rare,which were mainly observed in immuno-suppressed patients.All of the 18 cases of primary IPA were cured.Among the 65 secondary IPA patients,23 cases were cured,25 cases improved and discharged,12 cases discharged without medical advice,and 5 cases died.Conclusions：IPA oc-curred often in patients with underlying diseases and immune suppression,having atypical clinical manifestations and imaging findings.Patients with primary IPA have better prognosis than those with secondary IPA.

关 键 词：侵袭性肺曲霉病 影像学 临床特征 

分 类 号：R519[医药卫生—内科学]