紫外分光光度法测定阿替洛尔缓释微囊含量  

Determination of atenolol sustained-release microcapsules content by UV Spectrophotometr

作　　者：赛那[1] 金蓉[2] 顾艳丽[1] 贾颖[1] 

机构地区：[1]内蒙古医科大学药学院,呼和浩特010110 [2]内蒙古医科大学基础医学院,呼和浩特010110

出　　处：《北方药学》2015年第1期19-20,共2页Journal of North Pharmacy

摘　　要：目的：建立以紫外分光光度法测定阿替洛尔缓释微囊含量的方法。方法：将阿替洛尔缓释微囊研磨破碎,转移至容量瓶中,稀释后,在224nm处进行含量测定。结果：阿替洛尔在224nm处有最大吸收,辅料对测定无干扰。标准曲线方程：A=0.0355C＋0.0014,线性范围为2.5~20.0μg·ml^-1。回收率98.81%~99.36%,精密度和稳定性RSD均在2%以内,符合《中国药典》的要求。Objective： to establish a method for determination of atenolol sustained-release microcapsules content by ultraviolet spectrophotometry. Methods： to grind the atenolol sustained-release microcapsules,transferred to a volumetric flask,determining content at 224 nm. Results： the atenolol has maximum absorption at 224 nm,excipients do not interfere with the determination. standard curve equation： A=0.0355C＋0.0014,linear range is 2.5~20.0μg·ml^-1. The rate of recovery is 98.81%~99.36%,the precision and stability of RSD are within 2%.

关 键 词：紫外分光光度法 阿替洛尔缓释微囊 含量测定 

分 类 号：R943[医药卫生—药剂学]