咪康唑莫米松皮肤成膜凝胶的体外透皮研究  

Study on in Vitro Transdermal Permeability of Miconazole/Mometasone Skin Membrane Gel

作　　者：张丹霞[1] 陈惠英[1] 廖朝峰[1] 

机构地区：[1]广东省深圳市宝安区人民医院药剂科,深圳518101

出　　处：《北方药学》2015年第1期20-22,共3页Journal of North Pharmacy

摘　　要：目的：观察咪康唑莫米松皮肤成膜凝胶的体外透皮性能。方法：采用HPLC-DAD法测定咪康唑莫米松的含量,用Franz扩散池以离体鼠皮为透皮屏障进行体外透皮扩散试验,并计算咪康唑莫米松药物累积透皮量Q（Q咪和Q莫）和透皮速率常数J（J咪和J莫）。结果：咪康唑与莫米松的色谱峰能有效分离,进样量分别在1.0~400.0μg·ml-1和0.1~40.0μg·ml-1范围与各自峰面积呈良好线性关系,r值分别为0.9988和0.9982（n=6）,咪康唑与莫米松的J值分别为（17.810±0.558）μg·cm-2和（1.821±0.941）μg·cm-2·h-1,r值分别为0.9913和0.9908,无显著差异（P≥0.05）,咪康唑莫米松的透皮吸收行为均符合零级动力学方程。结论：咪康唑莫米松皮肤成膜凝胶,可开发为经皮给药制剂。Objective To observe the performance of in vitro transdermal permeability of miconazole/mometasone skin membrane gel.Methods The quantity of miconazole and mometasone was measured by the method of HPLC-DAD. In vitro transdermal diffusion experiment was carried out by Franz diffusion cell with excised rat skin as the transdermal barrier. The accumulative quantity of transdermal delivery of miconazole and mometasone Q（Qmiconazoleand Qmometasone）and the transdermal speed constant J（Jmiconazoleand J mometasone）were calculated. Results The chromatographic peak of miconazole could be effectively separated from that of mometasone. The injection volumes of miconazole and mometasone were respectively in the ranges of 1.0~400.0μg·ml-1（r=0.9988）and 0.1~40.0μg·ml-1（r=0.9982）（n=6）,which had good linear relationship with their respective peak areas. The values of Jmiconazoleand Jmometasonewere respectively（17.810±0.558）μg·cm^-2,h-1（r=0.9913）and（1.821±0.941）μg·cm-2,h^-1（r=0.9908）,while there was no significant difference between these two values（P≥0.05）. The transdermal absorption of miconazole and mometasone were in compliance with the zero-grade kinetics equation. Conclusion The miconazole/mometasone skin membrane gel could be developed as the transdermal delivery agent.

关 键 词：咪康唑/莫米松 皮肤成膜凝胶 体外透皮试验 FRANZ扩散池 离体鼠皮 

分 类 号：R965.3[医药卫生—药理学]