体检人群甲状腺激素水平调查  

Investigation of Serum Thyroid Hormone Levels in Healthy People

作　　者：刘春燕[1] 徐裔婷[1] 瞿卫[1] 

机构地区：[1]南京医科大学附属南京第一医院临床核医学中心,江苏南京210006

出　　处：《标记免疫分析与临床》2014年第6期642-644,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：目的 调查体检人群甲状腺激素水平,为健康指导及防治甲状腺疾病提供帮助.方法 采用微粒子化学发光法检测体检人群TSH、FT3和FT4.结果 ①随着年龄的增长,各年龄组TSH平均浓度呈上升趋势,FT3平均浓度呈下降趋势;②各年龄组甲状腺激素异常检出率存在差异.其中男性随着年龄的增长甲状腺激素异常检出比例呈上升趋势,年龄与患病率成较高的相关性;③＞ 50岁的人群甲减和亚甲减的患病率显著高于≤50岁的人群,差异有统计学意义（P＜0.05）;④女性甲状腺疾病患病率高于男性,其中甲减、亚临床甲减和甲亢的患病率差异具有统计学意义（P＜0.01）.结论 除了61～ 70年龄组的女性人群出现偏离外,所有男性组和其余各年龄段女性组,随着年龄的增长甲状腺激素异常检出比例总体呈上升趋势.50岁以上人群尤其是女性是患甲状腺疾病的高危人群,且甲状腺疾病多以甲状腺功能减退症和亚临床甲状腺功能减退症为主.Objective To investigate the thyroid hormone levels in healthy people at different age groups to provide guidance and assistance for preventing the thyroid diseases. Methods The serum levels of thyrotropin （TSH）, free thyroxine （FT4 ） and free triiodothyronine （FT3 ） in health examination people were detected by the microparticle chemiluminescence method. Results Along with the growth of the age, the average concentration of TSH was rising, and the Fr3 levels were decreased. The abnormality rate of thyroid hormone was different among those groups, which there was a positive correlation between the proportions of abnormal thyroid hormone hypothyroidism in aged people（ 〉, 50） was significantly higher than in young people（≤50） levels in man groups as age increased. The morbidity rate of hypothyroidism and mild （ P 〈 0. 05 ）. The morbidity rate of hypothyroidism, mild hypothyroidism and hyperthyroidism in women groups was significantly higher than in men groups（P 〈 0.01 ）. Conclusion Although the female population with 61-70 ages deviated, the abnormality proportion of thyroid hormone is rising along with the growth of the age. The elderly people （ 〉 50 years）, especially women, are at higher risk of suffering from thyroid disease, which are mostly hypothyroidism and subclinical hypothyroidism.

关 键 词：甲状腺激素 体检人群 患病率 性别 年龄 

分 类 号：R446.1[医药卫生—诊断学]