维吾尔族男性血清性激素结合球蛋白与2型糖尿病及其危险因素的相关性分析  

The Relationship Between SHBG and T2DM in Uighur Men

作　　者：王新玲[1] 梁蒙[1] 邢淑清[1] 苏热娅 郭艳英[1] 

机构地区：[1]新疆维吾尔自治区人民医院内分泌科

出　　处：《标记免疫分析与临床》2014年第6期661-664,667,共5页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探讨维族男性血清性激素结合球蛋白、性激素与2型糖尿病及其危险因素的关系。方法用随机对照方法纳入维族男性2型糖尿病患者81例和正常对照组65例,分别测量血压,检测空腹血糖、胰岛素、糖化血红蛋白、血脂、性激素、性激素结合球蛋白,计算体重指数和胰岛素抵抗指数,比较2型糖尿病组和对照组的上述指标水平,并探讨性激素、性激素结合球蛋白与2型糖尿病相关指标及其危险因素的关系。结果 2型糖尿病组空腹血糖、空腹胰岛素、糖化血红蛋白均高于正常对照组,而性激素结合球蛋白、睾酮低于正常对照组,P均小于0.05。应用Pearson相关以及Spearman秩相关作相关分析,维族男性2型糖尿病患者血清性激素结合球蛋白、血清睾酮均分别与体重指数(r=-0.485,r=-0.543)、空腹胰岛素(r=-0.467,r=-0.423)、甘油三酯(r=-0.442,r=-0.351)呈负相关,血清睾酮与高密度脂蛋白(r=0.317)呈正相关,P均小于0.05。结论在维族男性中,血清性激素结合球蛋白、血清睾酮可能是2型糖尿病的保护因素。Objective To investigate the relationship between sex hormone, SHBG and T2DM, and the risk factors of T2DM in Uighur men. Methods 81 patients of T2DM and 65 normal controls were selected by randomly in study to detect blood pressure, the level of FPG, FINS, HbAlc, blood lipids, sex hormone and SHBG. HOMA-IR and BMI were calculated. All these indexes were compared between T2DM group and normal control group. Results The levels of FPG, FINS and HbAlc in T2DM group were higher than those of normal control group, and the levels of SHBG and T were lower than those of normal control group when the age, BMI, blood pressure, blood lipids were all matched between the two groups （P 〈 0.05 ）. Using Pearson correlation analysis and Spearman rank correlation analysis, in Uighur men patients with type 2 diabetes, SHBG and serum testosterone were negatively correlated with BMI （ r = - 0. 485, r = - 0. 543 ）, FINS （ r = - 0. 467, r = - 0. 423 ）, TG（ r = - 0. 442, r = - 0. 351 ） respectively. Serum testosterone was positively correlated with HDL-c（r = 0. 317 ）. Conclusion SHBG and serum testosterone may be the protective factors of T2DM in Uighur men.

关 键 词：2型糖尿病 性激素结合球蛋白 睾酮 雌二醇 危险因素 

分 类 号：R587.1[医药卫生—内分泌]