消痰化瘀方对高脂血症患者颈动脉内膜中层厚度及血清炎症因子的影响  

Effect of Xiaotan Huayu Fang on Carotid Artery Intima-media Thickness and Inflammatory Factor in Serum of Patients with Hyperlipidemia

作　　者：张凯[1] 孙冠婴 陈玲玲[1,2] 关胜江[1] 张一昕[1] 郭秋红[1] 

机构地区：[1]河北中医学院,石家庄050200 [2]河北医科大学,050017

出　　处：《河北中医药学报》2014年第4期1-2,22,共3页Journal of Hebei Traditional Chinese Medicine and Pharmacology

基　　金：河北省科技攻关计划资助项目:No 12276104D-45

摘　　要：目的:研究消痰化瘀方对高脂血症合并颈动脉粥样硬化患者颈动脉内膜中层厚度(IMT)及血清炎症因子的影响,探讨其抗动脉粥样硬化(AS)的作用机制。方法:将110例高脂血症患者随机分为2组,治疗组服用消痰化瘀中药,对照组给予阿托伐他汀钙片,观察两组服药24周后血清白细胞介素-6(IL-6)、超敏-C反应蛋白(hs-CRP)、细胞间黏附分子-1(ICAM-1)的水平及颈动脉IMT的变化情况。结果:两组患者治疗后血清IL-6、hs-CRP和ICAM-1水平较治疗前降低,颈动脉IMT明显改善,差异具有显著性(P<0.05或P<0.01);治疗后两组比较,治疗组血清ICAM-1水平较对照组降低,差异具有显著性(P<0.05)。结论:消痰化瘀方具有显著的抗AS作用,这些作用可能与降低血清炎症因子有关。Objective： to study the effect of Xiaotan Huayu Fang on the IMT and inflammatory factor in patients with hyperlipidemia combined with atherosclerotic,and to explore its mechanism of anti-AS. Methods： 110 cases with hyperlipidemia were randomly divided into two groups： treatment group with Chinese medicine,control group with atorvastatin calcium tablets. Observe the IL-6,hsCRP,ICAM-1 contents and IMT changes after 24 weeks of administration. Results： IL-6,hs-CRP,ICAM-1 of both groups after treatment were lower than that before treatment,IMT were improved,with significant difference（ P〈0. 05 or P〈0. 01）; after treatment,ICAM-1 of treatment group was lower than that of control group with significant difference（ P〈0. 05）. Conclusion： Xiaotan Huayu Fang has significant function of anti-AS which may be relevant to reducing the inflammatory factor.

关 键 词：消痰化瘀方 高脂血症 动脉粥样硬化 颈动脉内膜中层厚度 白细胞介素-6 超敏-C反应蛋白 细胞间黏附分子-1 痰瘀 

分 类 号：R285.5[医药卫生—中药学]