青少年狼疮性肾炎中尿NGAL的水平检测及意义  

Detection and significance of neutrophil gelatinase associated lipocalin in urine of adolescent patients with systemic lupus erythematosus

作　　者：冯冰[1] 王浩[1] 沈元弟[1] 王琥[1] 王红娣[1] 

机构地区：[1]解放军第四一一医院肾内科,上海200081

出　　处：《实用临床医药杂志》2014年第23期39-41,共3页Journal of Clinical Medicine in Practice

摘　　要：目的探讨检测尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)在青少年狼疮性肾炎诊断中的临床意义。方法选择本院收治的30例系统性红斑狼疮性肾炎的青少年为观察组,收集其尿液和血清进行检测。同时选取同期体检的10例健康受试者作为对照组。对比分析2组24 h和48 h的尿NGAL和血清肌酐(sCr)水平变化。结果观察组尿NGAL检测结果与对照组具有显著性差异(P<0.01),而sCr只有发生严重肾功能衰竭时才与对照组有显著性差异(P<0.05,P<0.01)。对同一患者同时检测尿NGAL和sCr,其中有18例患者sCr仍在正常范围,而此时NGAL水平已经提示肾功能已出现部分损伤。结论 NGAL较之于sCr,能早期预测青少年狼疮性肾炎肾损害。Objective To explore the clinical significance of detecting neutrophil gelatinase associated lipocalin （NGAL） in the urine of adolescent patients with systemic lupus erythematosus （SLE）.Methods A total of 30 adolescent SLE patients admitted in our hospital served as observation group.The urine and serum were collected for detection.Meanwhile,another 10 healthy people undergoing physical examination were selected as control group.24 h and 48 h levels of urine NGAL and serum creatinine （sCr） in both groups were detected and compared.Results Urine NGAL showed significant difference between two groups （P 〈 0.01） while sCr only showed significant difference when patients in the observation group had severe renal failure （P 〈 0.0 5,P 〈 0.01）.NGAL and sCr were simultaneously detected for each patient in the observation group,in which the sCr level was still normal in 18 patients when NGAL level had suggested partial damage of renal function.Conclusion Compared with sCr,NGAL can predict the adolescent renal damage caused by SLE earlier.

关 键 词：中性粒细胞明胶酶 脂质运载蛋白 青少年狼疮性肾炎 血清肌酐 

分 类 号：R593.24[医药卫生—内科学]